EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.4.12 | fluphenazine | - |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.12 | sphingomyelin + H2O | Homo sapiens | - |
ceramide + phosphocholine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.4.12 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.4.12 | HCT-116 cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.12 | BODIPY FL C12-sphingomyelin + H2O | - |
Homo sapiens | BODIPY FL C12-ceramide + phosphocholine | - |
? | |
3.1.4.12 | sphingomyelin + H2O | - |
Homo sapiens | ceramide + phosphocholine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.4.12 | acid sphingomyelinase | - |
Homo sapiens |
3.1.4.12 | aSMase | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.1.4.12 | malfunction | acid sphingomyelinase inhibition causes cellular sphingomyelin accumulation, which induces cancer cell death specifically in hypoxic tumor spheroids | Homo sapiens |