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Literature summary extracted from

  • Chowdhary, S.; Bhattacharyya, R.; Banerjee, D.
    1-Naphthyl acetate a chromogenic substrate for the detection of erythrocyte acetylcholinesterase activity (2018), Biochimie, 154, 194-209 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 BW284c51 specific inhibitor of AChE Homo sapiens
3.1.1.7 dichlorvos
-
 Homo sapiens
3.1.1.7 malaoxon
-
 Homo sapiens
3.1.1.7 neostigmine as bromide or metasulfate, a non-specific cholinesterase inhibitor, used to inhibit hemolysate AChE activity in order to understand the specificity of 1-naphthyl acetate or acetylthiocholine for AChE Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.7 additional information
-
 additional information kinetics Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.7 acetylcholine + H2O Homo sapiens
-
 choline + acetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.7 erythrocyte
-
 Homo sapiens
-
3.1.1.7 hemolysate
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.7 1-naphthyl acetate + H2O a chromogenic substrate for detection of erythrocyte acetylcholinesterase activity Homo sapiens 1-naphthol + acetate
-
 ?
3.1.1.7 acetylcholine + H2O
-
 Homo sapiens choline + acetate
-
 ?
3.1.1.7 acetylthiocholine + H2O
-
 Homo sapiens thiocholine + acetate
-
 ?
3.1.1.7 additional information nonspecific inhibitor neostigmine is used to inhibit hemolysate AChE activity in order to understand the specificity of AChE for 1-naphthyl acetate or acetylthiocholine, substrate docking with AChE, BChE (EC 3.1.1.8), albumin and esterase D, acetylcholine docks with AChE, BChE, albumin and esterase D, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.7 AChE
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.7 22
-
 assay at room temperature Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.7 7.5
-
 assay at Homo sapiens