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Literature summary extracted from

  • Cividini, F.; Filoni, D.N.; Pesi, R.; Allegrini, S.; Camici, M.; Tozzi, M.G.
    IMP-GMP specific cytosolic 5'-nucleotidase regulates nucleotide pool and prodrug metabolism (2015), Biochim. Biophys. Acta, 1850, 1354-1361 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.5 beta-gamma-methylene-ATP
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.5 cytosol
-
 Homo sapiens 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.5 Mg2+ 20 mM used in assay conditions Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.5 5'-GMP + H2O Homo sapiens
-
 guanosine + phosphate
-
 r
3.1.3.5 5'-IMP + H2O Homo sapiens best substrate inosine + phosphate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.5 Homo sapiens P49902
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.5 HEK-293 cell
-
 Homo sapiens
-
3.1.3.5 HKiG2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.5 5'-GMP + H2O
-
 Homo sapiens guanosine + phosphate
-
 r
3.1.3.5 5'-IMP + H2O
-
 Homo sapiens inosine + phosphate
-
 r
3.1.3.5 5'-IMP + H2O best substrate Homo sapiens inosine + phosphate
-
 r
3.1.3.5 inosine + phosphate
-
 Homo sapiens 5'-IMP + H2O
-
 r

Synonyms

EC Number Synonyms Comment Organism
3.1.3.5 cN-II
-
 Homo sapiens
3.1.3.5 type II cytosolic 5'-nucleotidase
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.1.3.5 Homo sapiens the addition of ponasterone leads to overexpression of the enzyme assayed as phosphotransferase in an exposure time-dependent manner up