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Literature summary extracted from

  • Pawlik, K.; Kotowska, M.; Chater, K.; Kuczek, K.; Takano, E.
    A cryptic type I polyketide synthase (cpk) gene cluster in Streptomyces coelicolor A3(2) (2007), Arch. Microbiol., 187, 87-99 .
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.281 Streptomyces coelicolor Q9L8J0 cluster gene, contains subunit genes cpkA, cpkB and cpkC
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2.3.1.281 Streptomyces coelicolor A3(2) Q9L8J0 cluster gene, contains subunit genes cpkA, cpkB and cpkC
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2.6.1.115 Streptomyces coelicolor
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-
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2.6.1.115 Streptomyces coelicolor A3(2)
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-
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.281 6 malonyl-CoA + 5 NADPH + NADH + 6 H+
-
 Streptomyces coelicolor (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CoA + 5 NADP+ + NAD+ + 6 CO2 + 4 H2O
-
 ?
2.3.1.281 6 malonyl-CoA + 5 NADPH + NADH + 6 H+
-
 Streptomyces coelicolor A3(2) (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CoA + 5 NADP+ + NAD+ + 6 CO2 + 4 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.115 cpkG
-
 Streptomyces coelicolor

Expression

EC Number Organism Comment Expression
2.3.1.281 Streptomyces coelicolor polyketide synthase is expressed in transition phase additional information

General Information

EC Number General Information Comment Organism
2.3.1.281 physiological function the synthase consists of a loading module, five extension modules and a reductase as a terminal domain instead of a typical thioesterase. All acyltransferase domains are specific for a malonyl extender, and have a B-type ketoreductase. A gene disruption mutant does not exhibit any morphological, growth or antibiotic production (actinorhodin and undecyloprodigiosin) differences compared to the wild type, and no difference in antibacterial activity is observed as well as in the UV-Vis absorbance Streptomyces coelicolor
2.6.1.115 physiological function CpkG is encoded within the cpk gene cluster encoding a tyxpe I polyketide synthase Streptomyces coelicolor