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Literature summary extracted from

  • Bergeron, A.; Aragon, J.P.; Guillemette, C.; Hebert, A.; Sullivan, R.; Blondin, P.; Richard, F.J.
    Characterization of cAMP-phosphodiesterase activity in bovine seminal plasma (2016), Andrology, 4, 1123-1130 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.53 3-isobutyl-methylxanthine inhibitor of all PDE isoforms except PDE8 Bos taurus
3.1.4.53 Cilostamide inhibitor of isoform PDE3 Bos taurus
3.1.4.53 additional information the major enzyme activity (isoform PDE8) is insensitive towards 3-isobutyl-methylxanthine Bos taurus
3.1.4.53 papaverine inhibitor of isoform PDE10 Bos taurus
3.1.4.53 rolipram inhibitor of isoform PDE4 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.53 3',5'-cAMP + H2O Bos taurus
-
 5'-AMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.53 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.4.53 HiTrap-Q Sepharose column chromatography Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.53 epididymal fluid
-
 Bos taurus
-
3.1.4.53 epididymis
-
 Bos taurus
-
3.1.4.53 seminal plasma
-
 Bos taurus
-
3.1.4.53 seminal vesicle
-
 Bos taurus
-
3.1.4.53 spermatozoon
-
 Bos taurus
-
3.1.4.53 testis
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.53 3',5'-cAMP + H2O
-
 Bos taurus 5'-AMP
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.4.53 ? x * 60000, isoform PDE10 appears on SDS-PAGE as bands of 75000 and 60000 Da in size Bos taurus
3.1.4.53 ? x * 75000, isoform PDE10 appears on SDS-PAGE as bands of 75000 and 60000 Da in size Bos taurus

Synonyms

EC Number Synonyms Comment Organism
3.1.4.53 cAMP-PDE
-
 Bos taurus
3.1.4.53 cAMP-phosphodiesterase
-
 Bos taurus
3.1.4.53 PDE10A isoform Bos taurus
3.1.4.53 PDE3 isoform Bos taurus
3.1.4.53 PDE4 isoform Bos taurus
3.1.4.53 PDE8 isoform Bos taurus