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Literature summary extracted from

  • Tsolakis, A.V.; Grimelius, L.; Granerus, G.; Stridsberg, M.; Falkmer, S.E.; Janson, E.T.
    Histidine decarboxylase and urinary methylimidazoleacetic acid in gastric neuroendocrine cells and tumours (2015), World J. Gastroenterol., 21, 13240-13249 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.1.1.22 cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.22 L-histidine Homo sapiens
-
 histamine + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.22 Homo sapiens P19113
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.22 fundic mucosa
-
 Homo sapiens
-
4.1.1.22 gastric adenocarcinoma cell
-
 Homo sapiens
-
4.1.1.22 gastric mucosa the tumours are classified based on clinico-pathological criteria Homo sapiens
-
4.1.1.22 additional information histidine decarboxylase (HDC) expression in healthy and neoplastic gastric neuroendocrine cells in relationship to the main histamine metabolite, immunoreactive localization study, overview Homo sapiens
-
4.1.1.22 neuroendocrine tumor cell human oxyntic mucosa contains four major types of neuroendocrine cells: ECL, ghrelin, serotonin and somatostatin cells Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.22 L-histidine
-
 Homo sapiens histamine + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.22 HDC
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.22 pyridoxal 5'-phosphate
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
4.1.1.22 physiological function human oxyntic mucosa contains four major types of neuroendocrine cells (ECL, ghrelin, serotonin and somatostatin cells). ECL cells are the most abundant type, and they produce histamine. The histamine-synthesizing ability of ECL cells is based on cytosolic HDC. Histamine might be transported by VMAT-2 into the secretory vesicles Homo sapiens