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Literature summary extracted from

  • Schuemann, J.; Grevot, A.; Ledieu, D.; Wolf, A.; Schubart, A.; Piaia, A.; Sutter, E.; Cote, S.; Beerli, C.; Pognan, F.; Billich, A.; Moulin, P.; Walker, U.J.
    Reduced activity of sphingosine-1-phosphate lyase induces podocyte-related glomerular proteinuria, skin irritation, and platelet activation (2015), Toxicol. Pathol., 43, 694-703 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.2.27 [(4-benzyl-phthalazin-1-yl)-2-methylpiperazin-1-yl]-nicotinonitrile
-
 Mus musculus
4.1.2.27 [(4-benzyl-phthalazin-1-yl)-2-methylpiperazin-1-yl]-nicotinonitrile
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.2.27 sphinganine 1-phosphate Mus musculus
-
 phosphoethanolamine + palmitaldehyde
-
 ?
4.1.2.27 sphinganine 1-phosphate Rattus norvegicus
-
 phosphoethanolamine + palmitaldehyde
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.2.27 Mus musculus
-
-
-
4.1.2.27 Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.2.27 sphinganine 1-phosphate
-
 Mus musculus phosphoethanolamine + palmitaldehyde
-
 ?
4.1.2.27 sphinganine 1-phosphate
-
 Rattus norvegicus phosphoethanolamine + palmitaldehyde
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.2.27 S1P lyase
-
 Mus musculus
4.1.2.27 S1P lyase
-
 Rattus norvegicus
4.1.2.27 sphingosine-1-phosphate lyase
-
 Mus musculus
4.1.2.27 sphingosine-1-phosphate lyase
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
4.1.2.27 malfunction enzyme inhibition causes protein-losing glomerulopathy due to podocyte dysfunction, skin irritation, and platelet activation and may also be associated with pathological alterations in other tissues such as lung, liver, thymus, and the red blood cell system Mus musculus
4.1.2.27 malfunction enzyme inhibition causes protein-losing glomerulopathy due to podocyte dysfunction, skin irritation, and platelet activation and may also be associated with pathological alterations in other tissues such as lung, liver, thymus, and the red blood cell system Rattus norvegicus