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Literature summary extracted from

  • Ballatori, N.; Hammond, C.; Cunningham, J.; Krance, S.; Marchan, R.
    Molecular mechanisms of reduced glutathione transport Role of the MRP/CFTR/ABCC and OATP/SLC21A families of membrane proteins (2005), Toxicol. Appl. Pharmacol., 204, 238-255 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.6.2.3 glutathione
-
 Rattus norvegicus
7.6.2.3 glutathione
-
 Saccharomyces cerevisiae
7.6.2.3 glutathione
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.3 ATP + H2O + glutathione-S-conjugate[side 1] Rattus norvegicus
-
 ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?
7.6.2.3 ATP + H2O + glutathione-S-conjugate[side 1] Saccharomyces cerevisiae
-
 ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?
7.6.2.3 ATP + H2O + glutathione-S-conjugate[side 1] Homo sapiens
-
 ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?
7.6.2.3 ATP + H2O + leukotriene C4[side 1] Homo sapiens
-
 ADP + phosphate + leukotriene C4[side 2]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.3 Homo sapiens O15439
-
-
7.6.2.3 Homo sapiens O15440
-
-
7.6.2.3 Homo sapiens P33527
-
-
7.6.2.3 Homo sapiens Q92887
-
-
7.6.2.3 Rattus norvegicus
-
-
-
7.6.2.3 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.3 ATP + H2O + glutathione-S-conjugate[side 1]
-
 Rattus norvegicus ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?
7.6.2.3 ATP + H2O + glutathione-S-conjugate[side 1]
-
 Saccharomyces cerevisiae ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?
7.6.2.3 ATP + H2O + glutathione-S-conjugate[side 1]
-
 Homo sapiens ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?
7.6.2.3 ATP + H2O + leukotriene C4[side 1]
-
 Homo sapiens ADP + phosphate + leukotriene C4[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(17beta-estradiol)glutathione[side 1] substrate for isoform MRP4 Homo sapiens ADP + phosphate + S-(17beta-estradiol)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(4-(methylnitrosamino)-1-(3-pyridyl)1-1-butanol-glucuronidyl)glutathione[side 1] substrate for isoform MRP1 Homo sapiens ADP + phosphate + S-(4-(methylnitrosamino)-1-(3-pyridyl)1-1-butanol-glucuronidyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(6-mercaptopurinyl)glutathione[side 1] substrate for isoforms MRP4 and MRP5 Homo sapiens ADP + phosphate + S-(6-mercaptopurinyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(6-thioguaninyl)glutathione[side 1] substrate for isoforms MRP4 and MRP5 Homo sapiens ADP + phosphate + S-(6-thioguaninyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(aflatoxin B1)glutathione[side 1] substrate for isoform MRP1 Homo sapiens ADP + phosphate + S-(aflatoxin B1)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(cAMP)glutathione[side 1] substrate for isoform MRP4 Homo sapiens ADP + phosphate + S-(cAMP)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(cholyl)glutathione[side 1] substrate for isoform MRP4 Homo sapiens ADP + phosphate + S-(cholyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(daunorubicinyl)glutathione[side 1] substrate for isoform MRP1 Homo sapiens ADP + phosphate + S-(daunorubicinyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(doxorubicinyl)glutathione[side 1] substrate for isoform MRP1 Homo sapiens ADP + phosphate + S-(doxorubicinyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(estrone 3-sulfate)glutathione[side 1] substrate for isoform MRP1 Homo sapiens ADP + phosphate + S-(estrone 3-sulfate)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(etoposidyl)glutathione[side 1] substrate for isoforms MRP1 and MRP2 Homo sapiens ADP + phosphate + S-(etoposidyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(glycocholyl)glutathione[side 1] substrate for isoform MRP4 Homo sapiens ADP + phosphate + S-(glycocholyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(prostaglandin E1)glutathione[side 1] substrate for isoform MRP4 Homo sapiens ADP + phosphate + S-(prostaglandin E1)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(prostaglandin E2)glutathione[side 1] substrate for isoform MRP4 Homo sapiens ADP + phosphate + S-(prostaglandin E2)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(taurocholyl)glutathione[side 1] substrate for isoform MRP4 Homo sapiens ADP + phosphate + S-(taurocholyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(vinblastinyl)glutathione[side 1] substrate for isoforms MRP1 and MRP2 Homo sapiens ADP + phosphate + S-(vinblastinyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(vincristinyl)glutathione[side 1] substrate for isoforms MRP1 and MRP2 Homo sapiens ADP + phosphate + S-(vincristinyl)glutathione[side 2]
-
 ?
7.6.2.3 additional information glutathione is a direct, low-affinity substrate for enzyme isoform MRP1 and is required for the co-transport of certain MRP1 substrates but is itself not translocated across the membrane Homo sapiens ?
-
 ?
7.6.2.3 additional information the enzyme isoform MRP1 does not transport verapamil and bioflavonoids Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.6.2.3 bile pigment transporter-1
-
 Saccharomyces cerevisiae
7.6.2.3 Bpt1p
-
 Saccharomyces cerevisiae
7.6.2.3 glutathione S-conjugate transporter
-
 Rattus norvegicus
7.6.2.3 glutathione S-conjugate transporter
-
 Homo sapiens
7.6.2.3 GSH transporter
-
 Rattus norvegicus
7.6.2.3 GSH transporter
-
 Homo sapiens
7.6.2.3 Hgt1p
-
 Saccharomyces cerevisiae
7.6.2.3 high affinity glutathione transporter
-
 Saccharomyces cerevisiae
7.6.2.3 MRP1
-
 Homo sapiens
7.6.2.3 MRP2
-
 Homo sapiens
7.6.2.3 MRP4
-
 Homo sapiens
7.6.2.3 MRP5
-
 Homo sapiens
7.6.2.3 multidrug resistance-associated protein
-
 Homo sapiens
7.6.2.3 Oatp1
-
 Rattus norvegicus
7.6.2.3 Oatp2
-
 Rattus norvegicus
7.6.2.3 organic anion transporting polypeptide
-
 Rattus norvegicus
7.6.2.3 Ycf1p
-
 Saccharomyces cerevisiae
7.6.2.3 yeast cadmium factor-1
-
 Saccharomyces cerevisiae