Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Vinokur, J.M.; Cummins, M.C.; Korman, T.P.; Bowie, J.U.
    An adaptation to life in acid through a novel mevalonate pathway (2016), Sci. Rep., 6, 39737 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.110 expressed in Escherichia coli BL21(DE3) cells Thermoplasma acidophilum
4.1.1.110 expressed in Escherichia coli BL21(DE3) cells Picrophilus torridus
4.1.1.110 expressed in Escherichia coli BL21(DE3) cells Thermoplasma volcanium

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.110 89000
-
 gel filtration Thermoplasma acidophilum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.110 (R)-3,5-bisphosphomevalonate Thermoplasma acidophilum
-
 isopentenyl phosphate + CO2 + phosphate
-
 ?
4.1.1.110 (R)-3,5-bisphosphomevalonate Picrophilus torridus
-
 isopentenyl phosphate + CO2 + phosphate
-
 ?
4.1.1.110 (R)-3,5-bisphosphomevalonate Thermoplasma volcanium
-
 isopentenyl phosphate + CO2 + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.110 Picrophilus torridus Q6L1T9
-
-
4.1.1.110 Thermoplasma acidophilum
-
-
-
4.1.1.110 Thermoplasma volcanium Q97BM8
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.110 Ni-NTA column chromatography Thermoplasma acidophilum
4.1.1.110 Ni-NTA column chromatography Picrophilus torridus
4.1.1.110 Ni-NTA column chromatography Thermoplasma volcanium

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.110 (R)-3,5-bisphosphomevalonate
-
 Thermoplasma acidophilum isopentenyl phosphate + CO2 + phosphate
-
 ?
4.1.1.110 (R)-3,5-bisphosphomevalonate
-
 Picrophilus torridus isopentenyl phosphate + CO2 + phosphate
-
 ?
4.1.1.110 (R)-3,5-bisphosphomevalonate
-
 Thermoplasma volcanium isopentenyl phosphate + CO2 + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.110 homodimer 2 * 46300, calculated from amino acid sequence Thermoplasma acidophilum

Synonyms

EC Number Synonyms Comment Organism
4.1.1.110 MBD
-
 Thermoplasma acidophilum
4.1.1.110 MBD
-
 Picrophilus torridus
4.1.1.110 MBD
-
 Thermoplasma volcanium
4.1.1.110 mevalonate 3,5-bisphosphate decarboxylase
-
 Thermoplasma acidophilum
4.1.1.110 mevalonate 3,5-bisphosphate decarboxylase
-
 Picrophilus torridus
4.1.1.110 mevalonate 3,5-bisphosphate decarboxylase
-
 Thermoplasma volcanium
4.1.1.110 Mevalonate pyrophosphate decarboxylase
-
 Thermoplasma acidophilum
4.1.1.110 Mevalonate pyrophosphate decarboxylase
-
 Picrophilus torridus
4.1.1.110 Mevalonate pyrophosphate decarboxylase
-
 Thermoplasma volcanium