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Literature summary extracted from

  • Bali, S.; Lawrence, A.; Lobo, S.; Saraiva, L.; Golding, B.; Palmer, D.; Howard, M.; Ferguson, S.; Warren, M.
    Molecular hijacking of siroheme for the synthesis of heme and d1 heme (2011), Proc. Natl. Acad. Sci. USA, 108, 18260-18265 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.98.6 expressed in Escherichia coli Desulfovibrio desulfuricans
1.3.98.6 expresssion in Escherichia coli Desulfovibrio desulfuricans
4.1.1.111 expressed in Escherichia coli BL21(DE3) cells Desulfovibrio desulfuricans
4.1.1.111 expressed in Escherichia coli BL21(DE3) cells Desulfovibrio vulgaris

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.98.6 Fe-coproporphyrin III + S-adenosyl-L-methionine Desulfovibrio desulfuricans
-
 protoheme + CO2 + 5'-deoxyadenosine + L-methionine
-
 ?
4.1.1.111 siroheme Desulfovibrio desulfuricans
-
 12,18-didecarboxysiroheme + CO2
-
 ?
4.1.1.111 siroheme Desulfovibrio vulgaris
-
 12,18-didecarboxysiroheme + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.98.6 Desulfovibrio desulfuricans
-
-
-
1.3.98.6 Desulfovibrio desulfuricans A0A4P7UJ54
-
-
4.1.1.111 Desulfovibrio desulfuricans
-
-
-
4.1.1.111 Desulfovibrio vulgaris
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.98.6 Fe-coproporphyrin III + 2 S-adenosyl-L-methionine
-
 Desulfovibrio desulfuricans protoheme + 2 CO2 + 2 5'-deoxyadenosine + 2 L-methionine
-
 ?
1.3.98.6 Fe-coproporphyrin III + S-adenosyl-L-methionine
-
 Desulfovibrio desulfuricans protoheme + CO2 + 5'-deoxyadenosine + L-methionine
-
 ?
4.1.1.111 siroheme
-
 Desulfovibrio desulfuricans 12,18-didecarboxysiroheme + CO2
-
 ?
4.1.1.111 siroheme
-
 Desulfovibrio vulgaris 12,18-didecarboxysiroheme + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.98.6 ahbD
-
 Desulfovibrio desulfuricans
1.3.98.6 heme b synthase
-
 Desulfovibrio desulfuricans
4.1.1.111 AhbA-B
-
 Desulfovibrio desulfuricans
4.1.1.111 AhbA-B
-
 Desulfovibrio vulgaris
4.1.1.111 NirDL-G-H
-
 Desulfovibrio desulfuricans
4.1.1.111 NirDL-G-H
-
 Desulfovibrio vulgaris

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.98.6 4Fe-4S-center isolated protein forms a brown solution with a broad peak between 340 to 400 nm in the UV-visible spectrum Desulfovibrio desulfuricans
1.3.98.6 S-adenosyl-L-methionine
-
 Desulfovibrio desulfuricans