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Literature summary extracted from

  • Kaminski, L.; Eichler, J.
    Haloferax volcanii N-glycosylation delineating the pathway of dTDP-rhamnose biosynthesis (2014), PLoS ONE, 9, e97441 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.1.3.13 gene agl13, organized in a rmlABCD type cluster, sequence comparisons, functional recombinant expression of cellulose-bound CBD-Agl13 in Haloferax volcanii strain WR536 Haloferax volcanii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.1.3.13 dTDP-4-dehydro-6-deoxy-alpha-D-glucose Haloferax volcanii
-
 dTDP-4-dehydro-beta-L-rhamnose
-
 r
5.1.3.13 dTDP-4-dehydro-6-deoxy-alpha-D-glucose Haloferax volcanii WR536 / H53 / ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2
-
 dTDP-4-dehydro-beta-L-rhamnose
-
 r

Organism

EC Number Organism UniProt Comment Textmining
5.1.3.13 Haloferax volcanii D4GU69
-
-
5.1.3.13 Haloferax volcanii WR536 / H53 / ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2 D4GU69
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.1.3.13 recombinant cellulose-bound CBD-Agl13 from Haloferax volcanii strain WR536 by affinity chromatography Haloferax volcanii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.1.3.13 dTDP-4-dehydro-6-deoxy-alpha-D-glucose
-
 Haloferax volcanii dTDP-4-dehydro-beta-L-rhamnose
-
 r
5.1.3.13 dTDP-4-dehydro-6-deoxy-alpha-D-glucose
-
 Haloferax volcanii WR536 / H53 / ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2 dTDP-4-dehydro-beta-L-rhamnose
-
 r

Synonyms

EC Number Synonyms Comment Organism
5.1.3.13 Agl13
-
 Haloferax volcanii
5.1.3.13 dTDP-4-dehydro-6-deoxy-glucose-3,5-epimerase
-
 Haloferax volcanii
5.1.3.13 RmlC
-
 Haloferax volcanii

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
5.1.3.13 42
-
 recombinant cellulose-bound CBD-Agl13 Haloferax volcanii

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
5.1.3.13 7.2
-
 recombinant cellulose-bound CBD-Agl13 Haloferax volcanii

General Information

EC Number General Information Comment Organism
5.1.3.13 evolution Archaea synthesize nucleotide-activated rhamnose by a pathway similar to that employed by Bacteria and distinct from that used by Eukarya and viruses Haloferax volcanii
5.1.3.13 metabolism Archaea synthesize nucleotide-activated rhamnose by a pathway similar to that employed by Bacteria and distinct from that used by Eukarya and viruses. The pathwayto synthesize nucleotide-activated rhamnose involves Agl11 as a glucose-1-phosphate thymidylyltransferase, Agl12 as a dTDP-glucose-4,6-dehydratase, Agl13 as a dTDP-4-dehydro-6-deoxy-glucose-3,5-epimerase, and Agl14 as a dTDP-4-dehydrorhamnose reductase Haloferax volcanii
5.1.3.13 physiological function enzyme Agl13 is a dTDP-4-dehydro-6-deoxy-glucose-3,5-epimerase Haloferax volcanii