EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.3.4.5 | ATP + L-citrulline + L-aspartate | Leishmania donovani | the enzyme plays an important role as the rate-limiting step required for converting L-citrulline to argininosuccinate to provide arginine | AMP + diphosphate + 2-(Nomega-L-arginino)succinate | - |
? | |
6.3.4.5 | ATP + L-citrulline + L-aspartate | Leishmania donovani AG83 | the enzyme plays an important role as the rate-limiting step required for converting L-citrulline to argininosuccinate to provide arginine | AMP + diphosphate + 2-(Nomega-L-arginino)succinate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
6.3.4.5 | Leishmania donovani | H9BG20 | - |
- |
6.3.4.5 | Leishmania donovani AG83 | H9BG20 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
6.3.4.5 | promastigote | - |
Leishmania donovani | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.3.4.5 | ATP + L-citrulline + L-aspartate | - |
Leishmania donovani | AMP + diphosphate + 2-(Nomega-L-arginino)succinate | - |
? | |
6.3.4.5 | ATP + L-citrulline + L-aspartate | the enzyme plays an important role as the rate-limiting step required for converting L-citrulline to argininosuccinate to provide arginine | Leishmania donovani | AMP + diphosphate + 2-(Nomega-L-arginino)succinate | - |
? | |
6.3.4.5 | ATP + L-citrulline + L-aspartate | - |
Leishmania donovani AG83 | AMP + diphosphate + 2-(Nomega-L-arginino)succinate | - |
? | |
6.3.4.5 | ATP + L-citrulline + L-aspartate | the enzyme plays an important role as the rate-limiting step required for converting L-citrulline to argininosuccinate to provide arginine | Leishmania donovani AG83 | AMP + diphosphate + 2-(Nomega-L-arginino)succinate | - |
? |
EC Number | General Information | Comment | Organism |
---|---|---|---|
6.3.4.5 | malfunction | a cell line lacking two of three LdASS-/-/+ alleles, with greatly reduced argininosuccinate synthase activity, is generated by a double-targeted gene replacement strategy in Leishmania donovani promastigote | Leishmania donovani |
6.3.4.5 | metabolism | the enzyme plays an important role as the rate-limiting step required for converting L-citrulline to argininosuccinate to provide arginine | Leishmania donovani |
6.3.4.5 | physiological function | argininosuccinate synthase is important for Leishmania donovani to survive in stressed environments and can be exploited as anti-leishmanial drug target | Leishmania donovani |