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Literature summary extracted from
- Structural insight of DNA topoisomerases I from camptothecin-producing plants revealed by molecular dynamics simulations (2015), Phytochemistry, 113, 50-56 .
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 5.6.2.1 | expressed in Saccharomyces cerevisiae strain RS190 | Ophiorrhiza pumila |
| 5.6.2.1 | expressed in Saccharomyces cerevisiae strain RS190 | Nothapodytes nimmoniana |
| 5.6.2.1 | expressed in Saccharomyces cerevisiae strain RS190 | Camptotheca acuminata |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 5.6.2.1 | D710G | the mutant is resistant against topotecan | Ophiorrhiza pumila |
| 5.6.2.1 | V617G | the mutant is resistant against topotecan | Camptotheca acuminata |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.6.2.1 | camptothecin | - |
Camptotheca acuminata |  |
| 5.6.2.1 | camptothecin | - |
Nothapodytes nimmoniana | |
| 5.6.2.1 | camptothecin | - |
Ophiorrhiza pumila | |
| 5.6.2.1 | isorauhimbinic acid | - |
Camptotheca acuminata | |
| 5.6.2.1 | isorauhimbinic acid | - |
Nothapodytes nimmoniana | |
| 5.6.2.1 | isorauhimbinic acid | - |
Ophiorrhiza pumila | |
| 5.6.2.1 | topotecan | - |
Camptotheca acuminata | |
| 5.6.2.1 | topotecan | - |
Nothapodytes nimmoniana | |
| 5.6.2.1 | topotecan | - |
Ophiorrhiza pumila | |
| 5.6.2.1 | yohimbinic acid | - |
Camptotheca acuminata | |
| 5.6.2.1 | yohimbinic acid | - |
Nothapodytes nimmoniana | |
| 5.6.2.1 | yohimbinic acid | - |
Ophiorrhiza pumila | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.6.2.1 | Camptotheca acuminata | B2DDA7 | - |
- |
| 5.6.2.1 | Nothapodytes nimmoniana | A0A097ZNA3 | - |
- |
| 5.6.2.1 | Ophiorrhiza pumila | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 5.6.2.1 | leaf | - |
Nothapodytes nimmoniana | - |
| 5.6.2.1 | leaf | - |
Camptotheca acuminata | - |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.6.2.1 | DNA topoisomerase I | - |
Ophiorrhiza pumila |
| 5.6.2.1 | DNA topoisomerase I | - |
Nothapodytes nimmoniana |
| 5.6.2.1 | DNA topoisomerase I | - |
Camptotheca acuminata |
| 5.6.2.1 | Top1 | - |
Ophiorrhiza pumila |
| 5.6.2.1 | Top1 | - |
Nothapodytes nimmoniana |
| 5.6.2.1 | Top1 | - |
Camptotheca acuminata |
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Release 2023.1 (January 2023)
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