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Literature summary extracted from

  • Enright, E.F.; Govindarajan, K.; Darrer, R.; MacSharry, J.; Joyce, S.A.; Gahan, C.G.M.
    Gut microbiota-mediated bile acid transformations alter the cellular response to multidrug resistant transporter substrates in vitro focus on P-glycoprotein (2018), Mol. Pharm., 15, 5711-5727 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.6.2.2 chenodeoxycholic acid
-
 Homo sapiens
7.6.2.2 deoxycholic acid
-
 Homo sapiens
7.6.2.2 taurochenodeoxycholic acid
-
 Homo sapiens
7.6.2.2 taurodeoxycholic acid
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.2 plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.2 ATP + H2O + xenobiotic[side 1] Homo sapiens
-
 ADP + phosphate + xenobiotic[side 2]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.2 Homo sapiens P08183
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.6.2.2 Caco-2 cell
-
 Homo sapiens
-
7.6.2.2 enterocyte
-
 Homo sapiens
-
7.6.2.2 HT-29 cell
-
 Homo sapiens
-
7.6.2.2 T-84 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.2 ATP + H2O + cyclosporine A[side 1]
-
 Homo sapiens ADP + phosphate + cyclosporine A[side 2]
-
 ?
7.6.2.2 ATP + H2O + ethidium bromide[side 1]
-
 Homo sapiens ADP + phosphate + ethidium bromide[side 2]
-
 ?
7.6.2.2 ATP + H2O + rhodamine 6G[side 1]
-
 Homo sapiens ADP + phosphate + rhodamine 6G[side 2]
-
 ?
7.6.2.2 ATP + H2O + verapamil[side 1]
-
 Homo sapiens ADP + phosphate + verapamil[side 2]
-
 ?
7.6.2.2 ATP + H2O + xenobiotic[side 1]
-
 Homo sapiens ADP + phosphate + xenobiotic[side 2]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.6.2.2 ABCB1
-
 Homo sapiens
7.6.2.2 multidrug resistant transporter
-
 Homo sapiens
7.6.2.2 P-glycoprotein
-
 Homo sapiens
7.6.2.2 P-gp
-
 Homo sapiens