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Literature summary extracted from

  • Farine, L.; Jelk, J.; Choi, J.Y.; Voelker, D.R.; Nunes, J.; Smith, T.K.; Buetikofer, P.
    Phosphatidylserine synthase 2 and phosphatidylserine decarboxylase are essential for aminophospholipid synthesis in Trypanosoma brucei (2017), Mol. Microbiol., 104, 412-427 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
4.1.1.65 S318A mutation in putative cleavage motif, inhibits processing of the proenzyme. Mutant corrextly localizes to the mitochondrion Trypanosoma brucei

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.8.29 endoplasmic reticulum
-
 Trypanosoma brucei 5783
-
2.7.8.29 membrane presence of 8-9 membrane spanning regions Trypanosoma brucei 16020
-
4.1.1.65 mitochondrion
-
 Trypanosoma brucei 5739
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.29 Trypanosoma brucei Q57WJ1
-
-
2.7.8.29 Trypanosoma brucei 927/4 Q57WJ1
-
-
4.1.1.65 Trypanosoma brucei Q38DZ5
-
-
4.1.1.65 Trypanosoma brucei 927/4 GUTat10.1 Q38DZ5
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
4.1.1.65 proteolytic modification presence of a putative proteolytic PSD cleavage recognition motif, WGSS, amino acids 316-319 Trypanosoma brucei

Synonyms

EC Number Synonyms Comment Organism
2.7.8.29 PSS2
-
 Trypanosoma brucei
2.7.8.29 Tb927.7.3760
-
 Trypanosoma brucei
4.1.1.65 Tb927.9.10080
-
 Trypanosoma brucei

General Information

EC Number General Information Comment Organism
2.7.8.29 physiological function expression of PSS2 is necessary for normal growth of procyclic trypanosomes and PSS2 represents the unique route for phosphatidylserine formation in Trypanosoma brucei. Downregulation of TbPSS2 by RNAi for 3 days inhibits incorporation of serine into newly synthesized phosphatidylserine by 94.8 Trypanosoma brucei
4.1.1.65 physiological function after 4 days of gene silencing, procyclic forms of Trypanosoma brucei show a growth defect compared to control parasites, while growth of PSD-depleted bloodstream forms is only slightly affected. In both life cycle forms, down-regulation of TbPSD leads to mitochondrial fragmentation and a decrease in ATP production via oxidative phosphorylation of more than 75% in PSD-depleted mitochondria Trypanosoma brucei