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Literature summary extracted from

  • Tao, L.; Wilczek, J.; Odom, J.M.; Cheng, Q.
    Engineering a beta-carotene ketolase for astaxanthin production (2006), Metab. Eng., 8, 523-531 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.99.63 expression in Escherichia coli Sphingomonas sp. DC18

Protein Variants

EC Number Protein Variants Comment Organism
1.14.99.63 A205V mutation improves astaxanthin production Sphingomonas sp. DC18
1.14.99.63 A208V mutation improves astaxanthin production Sphingomonas sp. DC18
1.14.99.63 A215T mutation improves astaxanthin production Sphingomonas sp. DC18
1.14.99.63 F213L mutant enzyme shows high improvement for astaxanthin production and decreased activity for canthaxanthin production Sphingomonas sp. DC18
1.14.99.63 F213L mutation improves astaxanthin production Sphingomonas sp. DC18
1.14.99.63 H96L mutation improves astaxanthin production Sphingomonas sp. DC18
1.14.99.63 R203W mutation improves astaxanthin production Sphingomonas sp. DC18
1.14.99.63 R203W/F213L mutant enzyme shows high improvement for astaxanthin production and decreased activity for canthaxanthin production Sphingomonas sp. DC18
1.14.99.63 R203W/F213L mutation improves astaxanthin production Sphingomonas sp. DC18

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.99.63 beta-carotene + 2 reduced acceptor + 2 O2 Sphingomonas sp. DC18
-
 echinenone + 2 acceptor + 3 H2O
-
 ?
1.14.99.63 echinenone + 2 reduced acceptor + 2 O2 Sphingomonas sp. DC18
-
 canthaxanthin + 2 acceptor + 3 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.63 Sphingomonas sp. DC18 A3QQZ2
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.63 beta-carotene + 2 reduced acceptor + 2 O2
-
 Sphingomonas sp. DC18 echinenone + 2 acceptor + 3 H2O
-
 ?
1.14.99.63 echinenone + 2 reduced acceptor + 2 O2
-
 Sphingomonas sp. DC18 canthaxanthin + 2 acceptor + 3 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.99.63 CrtW
-
 Sphingomonas sp. DC18