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Literature summary extracted from

  • Ogino, M.; Ogino, T.
    5'-Phospho-RNA acceptor specificity of GDP polyribonucleotidyltransferase of vesicular stomatitis virus in mRNA capping (2017), J. Virol., 91, e02322-16 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.88 2',3'-dideoxyguanosine 5'-diphosphate
-
 vesicular stomatitis virus
2.7.7.88 2'-deoxyguanosine 5'-diphosphate
-
 vesicular stomatitis virus
2.7.7.88 2,6-diaminopurine-riboside 5'-diphosphate
-
 vesicular stomatitis virus
2.7.7.88 2-aminopurine-riboside 5'-diphosphate
-
 vesicular stomatitis virus
2.7.7.88 3'-deoxyguanosine 5'-diphosphate
-
 vesicular stomatitis virus
2.7.7.88 7-deazaguanosine 5'-diphosphate
-
 vesicular stomatitis virus
2.7.7.88 7-methylguanosine 5'-diphosphate
-
 vesicular stomatitis virus
2.7.7.88 ADP
-
 vesicular stomatitis virus
2.7.7.88 IDP
-
 vesicular stomatitis virus
2.7.7.88 ribavirin 5'-diphosphate
-
 vesicular stomatitis virus
2.7.7.88 XDP
-
 vesicular stomatitis virus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.88 0.00003
-
 GDP at pH 7.5 and 30°C vesicular stomatitis virus
2.7.7.88 0.0004
-
 5'-triphospho-AACAG at pH 7.5 and 30°C vesicular stomatitis virus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.88 5'-triphospho-mRNA + GDP vesicular stomatitis virus
-
 diphosphate + guanosine 5'-triphospho-mRNA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.88 vesicular stomatitis virus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.88 5'-triphospho-AACAG + 2,6-diaminopurine-riboside 5'-diphosphate
-
 vesicular stomatitis virus diphosphate + 2,6-diaminopurine-riboside 5'-triphospho-AACAG
-
 ?
2.7.7.88 5'-triphospho-AACAG + 7-deazaguanosine 5'-diphosphate
-
 vesicular stomatitis virus diphosphate + 7-deazaguanosine 5'-triphospho-AACAG
-
 ?
2.7.7.88 5'-triphospho-AACAG + 7-methylguanosine 5'-diphosphate
-
 vesicular stomatitis virus diphosphate + 7-methylguanosine 5'-triphospho-AACAG
-
 ?
2.7.7.88 5'-triphospho-AACAG + GDP
-
 vesicular stomatitis virus diphosphate + guanosine 5'-triphospho-AACAG
-
 ?
2.7.7.88 5'-triphospho-mRNA + GDP
-
 vesicular stomatitis virus diphosphate + guanosine 5'-triphospho-mRNA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.88 GDP polyribonucleotidyltransferase
-
 vesicular stomatitis virus
2.7.7.88 L protein
-
 vesicular stomatitis virus
2.7.7.88 PRNTase
-
 vesicular stomatitis virus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.7.88 0.000036
-
 2,6-diaminopurine-riboside 5'-diphosphate at pH 7.5 and 30°C vesicular stomatitis virus
2.7.7.88 0.000038
-
 7-methylguanosine 5'-diphosphate at pH 7.5 and 30°C vesicular stomatitis virus
2.7.7.88 0.00004
-
 7-deazaguanosine 5'-diphosphate at pH 7.5 and 30°C vesicular stomatitis virus
2.7.7.88 0.000053
-
 2'-deoxyguanosine 5'-diphosphate at pH 7.5 and 30°C vesicular stomatitis virus
2.7.7.88 0.000058
-
 3'-deoxyguanosine 5'-diphosphate at pH 7.5 and 30°C vesicular stomatitis virus
2.7.7.88 0.00014
-
 2-aminopurine-riboside 5'-diphosphate at pH 7.5 and 30°C vesicular stomatitis virus
2.7.7.88 0.00038
-
 2',3'-dideoxyguanosine 5'-diphosphate at pH 7.5 and 30°C vesicular stomatitis virus
2.7.7.88 0.0007
-
 IDP at pH 7.5 and 30°C vesicular stomatitis virus
2.7.7.88 0.00095
-
 ribavirin 5'-diphosphate at pH 7.5 and 30°C vesicular stomatitis virus
2.7.7.88 0.0026
-
 ADP at pH 7.5 and 30°C vesicular stomatitis virus
2.7.7.88 0.0064
-
 XDP at pH 7.5 and 30°C vesicular stomatitis virus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.7.88 0.00037
-
 at pH 7.5 and 30°C vesicular stomatitis virus 2,6-diaminopurine-riboside 5'-diphosphate
2.7.7.88 0.00039
-
 at pH 7.5 and 30°C vesicular stomatitis virus 7-methylguanosine 5'-diphosphate
2.7.7.88 0.0004
-
 at pH 7.5 and 30°C vesicular stomatitis virus 7-deazaguanosine 5'-diphosphate
2.7.7.88 0.00053
-
 at pH 7.5 and 30°C vesicular stomatitis virus 2'-deoxyguanosine 5'-diphosphate
2.7.7.88 0.00057
-
 at pH 7.5 and 30°C vesicular stomatitis virus 3'-deoxyguanosine 5'-diphosphate
2.7.7.88 0.0013
-
 at pH 7.5 and 30°C vesicular stomatitis virus 2-aminopurine-riboside 5'-diphosphate
2.7.7.88 0.0035
-
 at pH 7.5 and 30°C vesicular stomatitis virus 2',3'-dideoxyguanosine 5'-diphosphate
2.7.7.88 0.0064
-
 at pH 7.5 and 30°C vesicular stomatitis virus IDP
2.7.7.88 0.0086
-
 at pH 7.5 and 30°C vesicular stomatitis virus ribavirin 5'-diphosphate
2.7.7.88 0.023
-
 at pH 7.5 and 30°C vesicular stomatitis virus ADP
2.7.7.88 0.058
-
 at pH 7.5 and 30°C vesicular stomatitis virus XDP