BRENDA - Enzyme Database

Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2

Mikawa, T.; Maruyama, T.; Okamoto, K.; Nakagama, H.; Lleonart, M.E.; Tsusaka, T.; Hori, K.; Murakami, I.; Izumi, T.; Takaori-Kondo, A.; Yokode, M.; Peters, G.; Beach, D.; Kondoh, H.; J. Cell Biol. 204, 729-745 (2014)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.4.2.11
2-phospho-D-glycerate
Homo sapiens
-
3-phospho-D-glycerate
-
-
?
5.4.2.11
2-phospho-D-glycerate
Mus musculus
-
3-phospho-D-glycerate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.4.2.11
Homo sapiens
P15259
-
-
5.4.2.11
Mus musculus
O70250
-
-
Posttranslational Modification
EC Number
Posttranslational Modification
Commentary
Organism
5.4.2.11
phosphoprotein
Pak1-mediated phosphorylation of phosphoglycerate mutase predisposes the enzyme to ubiquitin-mediated degradation
Homo sapiens
5.4.2.11
phosphoprotein
Pak1-mediated phosphorylation of phosphoglycerate mutase predisposes the enzyme to ubiquitin-mediated degradation
Mus musculus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.4.2.11
HCT-116 cell
-
Homo sapiens
-
5.4.2.11
HEK-293T cell
-
Homo sapiens
-
5.4.2.11
HeLa cell
-
Homo sapiens
-
5.4.2.11
HT-29 cell
-
Homo sapiens
-
5.4.2.11
IMR-90 cell
-
Homo sapiens
-
5.4.2.11
MEF cell
-
Mus musculus
-
5.4.2.11
RKO cell
-
Homo sapiens
-
5.4.2.11
SW-620 cell
-
Homo sapiens
-
5.4.2.11
TIG3 cell
-
Homo sapiens
-
5.4.2.11
WI-38 cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.4.2.11
2-phospho-D-glycerate
-
748279
Homo sapiens
3-phospho-D-glycerate
-
-
-
?
5.4.2.11
2-phospho-D-glycerate
-
748279
Mus musculus
3-phospho-D-glycerate
-
-
-
?
5.4.2.11
additional information
Mdm2 is a direct binding partner and ubiquitin ligase for the enzyme in cultured cells and in vitro
748279
Homo sapiens
?
-
-
-
-
5.4.2.11
additional information
Mdm2 is a direct binding partner and ubiquitin ligase for the enzyme in cultured cells and in vitro
748279
Mus musculus
?
-
-
-
-
Subunits
EC Number
Subunits
Commentary
Organism
5.4.2.11
?
x * 30000, SDS-PAGE
Homo sapiens
5.4.2.11
?
x * 30000, SDS-PAGE
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.4.2.11
2-phospho-D-glycerate
Homo sapiens
-
3-phospho-D-glycerate
-
-
?
5.4.2.11
2-phospho-D-glycerate
Mus musculus
-
3-phospho-D-glycerate
-
-
?
Posttranslational Modification (protein specific)
EC Number
Posttranslational Modification
Commentary
Organism
5.4.2.11
phosphoprotein
Pak1-mediated phosphorylation of phosphoglycerate mutase predisposes the enzyme to ubiquitin-mediated degradation
Homo sapiens
5.4.2.11
phosphoprotein
Pak1-mediated phosphorylation of phosphoglycerate mutase predisposes the enzyme to ubiquitin-mediated degradation
Mus musculus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.4.2.11
HCT-116 cell
-
Homo sapiens
-
5.4.2.11
HEK-293T cell
-
Homo sapiens
-
5.4.2.11
HeLa cell
-
Homo sapiens
-
5.4.2.11
HT-29 cell
-
Homo sapiens
-
5.4.2.11
IMR-90 cell
-
Homo sapiens
-
5.4.2.11
MEF cell
-
Mus musculus
-
5.4.2.11
RKO cell
-
Homo sapiens
-
5.4.2.11
SW-620 cell
-
Homo sapiens
-
5.4.2.11
TIG3 cell
-
Homo sapiens
-
5.4.2.11
WI-38 cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.4.2.11
2-phospho-D-glycerate
-
748279
Homo sapiens
3-phospho-D-glycerate
-
-
-
?
5.4.2.11
2-phospho-D-glycerate
-
748279
Mus musculus
3-phospho-D-glycerate
-
-
-
?
5.4.2.11
additional information
Mdm2 is a direct binding partner and ubiquitin ligase for the enzyme in cultured cells and in vitro
748279
Homo sapiens
?
-
-
-
-
5.4.2.11
additional information
Mdm2 is a direct binding partner and ubiquitin ligase for the enzyme in cultured cells and in vitro
748279
Mus musculus
?
-
-
-
-
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
5.4.2.11
?
x * 30000, SDS-PAGE
Homo sapiens
5.4.2.11
?
x * 30000, SDS-PAGE
Mus musculus
Expression
EC Number
Organism
Commentary
Expression
5.4.2.11
Homo sapiens
stress-induced down-regulation of the enzyme protein is observed in human primary fibroblasts but not in cancer cell lines
down
Expression (protein specific)
EC Number
Organism
Commentary
Expression
5.4.2.11
Homo sapiens
stress-induced down-regulation of the enzyme protein is observed in human primary fibroblasts but not in cancer cell lines
down