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Literature summary extracted from

  • Mikawa, T.; Maruyama, T.; Okamoto, K.; Nakagama, H.; Lleonart, M.E.; Tsusaka, T.; Hori, K.; Murakami, I.; Izumi, T.; Takaori-Kondo, A.; Yokode, M.; Peters, G.; Beach, D.; Kondoh, H.
    Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2 (2014), J. Cell Biol., 204, 729-745 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.4.2.11 2-phospho-D-glycerate Homo sapiens
-
 3-phospho-D-glycerate
-
 ?
5.4.2.11 2-phospho-D-glycerate Mus musculus
-
 3-phospho-D-glycerate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.4.2.11 Homo sapiens P15259
-
-
5.4.2.11 Mus musculus O70250
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
5.4.2.11 phosphoprotein Pak1-mediated phosphorylation of phosphoglycerate mutase predisposes the enzyme to ubiquitin-mediated degradation Homo sapiens
5.4.2.11 phosphoprotein Pak1-mediated phosphorylation of phosphoglycerate mutase predisposes the enzyme to ubiquitin-mediated degradation Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.4.2.11 HCT-116 cell
-
 Homo sapiens
-
5.4.2.11 HEK-293T cell
-
 Homo sapiens
-
5.4.2.11 HeLa cell
-
 Homo sapiens
-
5.4.2.11 HT-29 cell
-
 Homo sapiens
-
5.4.2.11 IMR-90 cell
-
 Homo sapiens
-
5.4.2.11 MEF cell
-
 Mus musculus
-
5.4.2.11 RKO cell
-
 Homo sapiens
-
5.4.2.11 SW-620 cell
-
 Homo sapiens
-
5.4.2.11 TIG3 cell
-
 Homo sapiens
-
5.4.2.11 WI-38 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.2.11 2-phospho-D-glycerate
-
 Homo sapiens 3-phospho-D-glycerate
-
 ?
5.4.2.11 2-phospho-D-glycerate
-
 Mus musculus 3-phospho-D-glycerate
-
 ?
5.4.2.11 additional information Mdm2 is a direct binding partner and ubiquitin ligase for the enzyme in cultured cells and in vitro Homo sapiens ?
-
 ?
5.4.2.11 additional information Mdm2 is a direct binding partner and ubiquitin ligase for the enzyme in cultured cells and in vitro Mus musculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
5.4.2.11 ? x * 30000, SDS-PAGE Homo sapiens
5.4.2.11 ? x * 30000, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
5.4.2.11 alpha-PGAM
-
 Homo sapiens
5.4.2.11 alpha-PGAM
-
 Mus musculus
5.4.2.11 PGAM2
-
 Homo sapiens
5.4.2.11 PGAM2
-
 Mus musculus

Expression

EC Number Organism Comment Expression
5.4.2.11 Homo sapiens stress-induced down-regulation of the enzyme protein is observed in human primary fibroblasts but not in cancer cell lines down