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Literature summary extracted from

  • Kleinboelting, S.; Ramos-Espiritu, L.; Buck, H.; Colis, L.; van den Heuvel, J.; Glickman, J.F.; Levin, L.R.; Buck, J.; Steegborn, C.
    Bithionol potently inhibits human soluble adenylyl cyclase through binding to the allosteric activator site (2016), J. Biol. Chem., 291, 9776-9784 .
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.6.1.1 in complex with inhibitor bithionol. The inhibitor binds to the isoform Adcy10-specific, allosteric binding site for the physiological activator bicarbonate. Inhibition follows an allosteric mechanism, the compound induces rearrangements of substrate binding residues and of Arg176, a trigger between the active site and allosteric site Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.1 bithionol potent, isoform Adcy10-specific inhibitor, noncompetitive with respect to ATP Homo sapiens
4.6.1.1 Hexachlorophene potent, isoform Adcy10-specific inhibitor, noncompetitive with respect to ATP Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.6.1.1 soluble
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.1 Homo sapiens Q96PN6 isoform Adcy10
-

Synonyms

EC Number Synonyms Comment Organism
4.6.1.1 adenylate cyclase type 10
-
 Homo sapiens