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Literature summary extracted from

  • Pailler, J.; Aucher, W.; Pires, M.; Buddelmeijer, N.
    Phosphatidylglycerol prolipoprotein diacylglyceryl transferase (Lgt) of Escherichia coli has seven transmembrane segments, and its essential residues are embedded in the membrane (2012), J. Bacteriol., 194, 2142-2151 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.145 D129A the mutation is not essential for enzyme activity Escherichia coli
2.5.1.145 E151A the mutation is essential for enzyme activity Escherichia coli
2.5.1.145 E243A the mutation is essential for enzyme activity Escherichia coli
2.5.1.145 G104A the mutation is not essential for enzyme activity Escherichia coli
2.5.1.145 G98A the mutation is not essential for enzyme activity Escherichia coli
2.5.1.145 H103Q the mutation is not essential for enzyme activity Escherichia coli
2.5.1.145 R143A the mutation is essential for enzyme activity Escherichia coli
2.5.1.145 R239A the mutation is essential for enzyme activity Escherichia coli

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.5.1.145 membrane an integral inner membrane protein, the enzyme's signature motif faces the periplasm Escherichia coli 16020
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.145 L-1-phosphatidyl-sn-glycerol + a [prolipoprotein]-L-cysteine Escherichia coli
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 sn-glycerol 1-phosphate + an [prolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.145 Escherichia coli P60955
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.145 L-1-phosphatidyl-sn-glycerol + a [prolipoprotein]-L-cysteine
-
 Escherichia coli sn-glycerol 1-phosphate + an [prolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.145 LGT
-
 Escherichia coli
2.5.1.145 phosphatidylglycerol::prolipoprotein diacylglyceryl transferase
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 Escherichia coli