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Literature summary extracted from

  • Ren, L.Q.; Chen, M.; Hultborn, H.; Guo, S.; Zhang, Y.; Zhang, M.
    Heterogenic distribution of aromatic L-amino acid decarboxylase neurons in the rat spinal cord (2017), Front. Integr. Neurosci., 11, 31 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.28 5-hydroxy-L-tryptophan Rattus norvegicus
-
 5-hydroxytryptamine + CO2
-
 ?
4.1.1.28 L-Dopa Rattus norvegicus
-
 dopamine + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.28 Rattus norvegicus P14173
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.28 brain in the gray matter, AADC neurons are not only found in the region around the central canal but also in the dorsal horn, intermediate zone, and ventral horn. In the white matter a large number of glial cells are AADC-immunopositive in different spinal segments and the vast majority of these cells express oligodendrocyte and radial glial phenotypes. Additionally, a small number of AADC neurons are found in the white matter along the ventral median fissure Rattus norvegicus
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4.1.1.28 additional information immunohistochemic localization study using anti-AADC antibodies with AADC immunoreactivity by the avidin-biotin complex (ABC) peroxidase immunohistochemistry, overview. The diverse morphological characteristics of the AADC cells suggests that they can be further divided into several subtypes Rattus norvegicus
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4.1.1.28 neuron AADC neurons, the shapes and sizes of AADC neurons vary according to their location Rattus norvegicus
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4.1.1.28 spinal cord
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 Rattus norvegicus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.28 5-hydroxy-L-tryptophan
-
 Rattus norvegicus 5-hydroxytryptamine + CO2
-
 ?
4.1.1.28 L-Dopa
-
 Rattus norvegicus dopamine + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.28 AADC
-
 Rattus norvegicus
4.1.1.28 Aromatic L-amino acid decarboxylase
-
 Rattus norvegicus
4.1.1.28 L-amino acid decarboxylase
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
4.1.1.28 physiological function aromatic L-amino acid decarboxylase (AADC) is an essential enzyme in the synthesis of serotonin, dopamine, and certain trace amines and is active in a variety of organs including the brain and spinal cord Rattus norvegicus