EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.2.1.3 | HOCl | exposure of human coronary artery endothelial cells to 0-50 microM HOCl or 0-150 microM HOSCN results in an increase in intracellular iron, loss of aconitase activity and a loss of mitochondrial aconitase protein. Cytosolic aconitase is not affected | Homo sapiens | |
4.2.1.3 | HOSCN | exposure of human coronary artery endothelial cells to 0-50 microM HOCl or 0-150 microM HOSCN results in an increase in intracellular iron, loss of aconitase activity and a loss of mitochondrial aconitase protein. Cytosolic aconitase is not affected. HOSCN induces rapid and efficient release of iron from aconitase. Blocking the [4Fe-4 S] cluster inhibits HOSCN-mediated inactivation | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.2.1.3 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
4.2.1.3 | artery | coronary artery endothelial cells | Homo sapiens | - |
4.2.1.3 | endothelium | coronary artery endothelial cells | Homo sapiens | - |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
4.2.1.3 | [4Fe-4S]-center | HOSCN induces rapid and efficient release of iron from aconitase. Blocking the [4Fe-4 S] cluster inhibits HOSCN-mediated inactivation | Homo sapiens |