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Literature summary extracted from

  • Lan, Y.L.; Yu, Z.L.; Lou, J.C.; Ma, X.C.; Zhang, B.
    Update on the effects of the sodium pump alpha1 subunit on human glioblastoma from the laboratory to the clinic (2018), Expert Opin. Investig. Drugs, 27, 753-763 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.2.3 bufalin
-
 Homo sapiens
7.2.2.3 digoxin
-
 Homo sapiens
7.2.2.3 hellebrin
-
 Homo sapiens
7.2.2.3 istaroxime
-
 Homo sapiens
7.2.2.3 oleandrin
-
 Homo sapiens
7.2.2.3 Ouabain shows moderate selectivity (approximately 2.5fold) for alpha1 over alpha2 subunits of the enzyme Homo sapiens
7.2.2.3 perillyl alcohol
-
 Homo sapiens
7.2.2.3 UNBS1450 specific inhibitor Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.3 membrane transmembrane protein Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.3 ATP + H2O + Na+[side 1] Homo sapiens
-
 ADP + phosphate + Na+[side 2]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.3 Homo sapiens P05023
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
7.2.2.3 phosphoprotein
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.3 glioblastoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.3 ATP + H2O + Li+[side 1]
-
 Homo sapiens ADP + phosphate + Li+[side 2]
-
 ?
7.2.2.3 ATP + H2O + Na+[side 1]
-
 Homo sapiens ADP + phosphate + Na+[side 2]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.2.2.3 Na+/K+-ATPase sodium pump
-
 Homo sapiens
7.2.2.3 sodium pump alpha1 subunit
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
7.2.2.3 Homo sapiens expression of the sodium pump alpha1 subunit in glioblastoma tissues is generally higher than that in normal tissues up

General Information

EC Number General Information Comment Organism
7.2.2.3 physiological function the sodium pump alpha1 subunit potentially mediates various antiglioblastoma signaling pathways and affects the sensitivity of glioblastoma cells to drugs Homo sapiens