EC Number | Cloned (Comment) | Organism |
---|---|---|
1.3.1.9 | overexpression in Escherichia coli | Mycobacterium tuberculosis |
1.3.1.118 | overexpression in Escherichia coli | Mycobacterium tuberculosis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.3.1.9 | isoniazid | fast and efficient inhibition of InhA in the presence of NADH and INH using MnIII-pyrophosphate as nonenzymatic reagent. This chemical oxidant might be a useful tool for further mechanistic studies of isoniazid activation in attempts to establish the exact structures of isoniazid reactive species and InhA inhibitor complex(es). | Mycobacterium tuberculosis | |
1.3.1.118 | isoniazid | fast and efficient inhibition of InhA in the presence of NADH and INH using MnIII-pyrophosphate as nonenzymatic reagent. This chemical oxidant might be a useful tool for further mechanistic studies of isoniazid activation in attempts to establish the exact structures of isoniazid reactive species and InhA inhibitor complex(es). | Mycobacterium tuberculosis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.3.1.9 | Mycobacterium tuberculosis | - |
- |
- |
1.3.1.118 | Mycobacterium tuberculosis | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.3.1.9 | - |
Mycobacterium tuberculosis |
1.3.1.118 | - |
Mycobacterium tuberculosis |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.1.9 | trans-2-decenoyl-CoA + NADH + H+ | - |
Mycobacterium tuberculosis | decanoyl-CoA + NAD+ | - |
? | |
1.3.1.118 | trans-2-decenoyl-CoA + NADH + H+ | - |
Mycobacterium tuberculosis | decanoyl-CoA + NAD+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.3.1.9 | InhA | - |
Mycobacterium tuberculosis |
1.3.1.118 | InhA | - |
Mycobacterium tuberculosis |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.3.1.9 | 25 | - |
assay at | Mycobacterium tuberculosis |
1.3.1.118 | 25 | - |
assay at | Mycobacterium tuberculosis |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.3.1.9 | 7.5 | - |
assay at | Mycobacterium tuberculosis |
1.3.1.118 | 7.5 | - |
assay at | Mycobacterium tuberculosis |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.3.1.9 | NADH | - |
Mycobacterium tuberculosis | |
1.3.1.118 | NADH | - |
Mycobacterium tuberculosis |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.3.1.9 | metabolism | the enzyme is involved on the biosynthetic pathway for mycolic acids | Mycobacterium tuberculosis |
1.3.1.118 | metabolism | the enzyme is involved on the biosynthetic pathway for mycolic acids | Mycobacterium tuberculosis |