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Literature summary extracted from

  • Horsey, A.J.; Cox, M.H.; Sarwat, S.; Kerr, I.D.
    The multidrug transporter ABCG2 still more questions than answers (2016), Biochem. Soc. Trans., 44, 824-830 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.6.2.2 expressed in Sf9 insect cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.2 membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.2 ATP + H2O + xenobiotic[side 1] Homo sapiens
-
 ADP + phosphate + xenobiotic[side 2]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.2 Homo sapiens Q9UNQ0
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.6.2.2 breast cancer cell
-
 Homo sapiens
-
7.6.2.2 duodenum
-
 Homo sapiens
-
7.6.2.2 epithelial cell
-
 Homo sapiens
-
7.6.2.2 gastrointestinal tract
-
 Homo sapiens
-
7.6.2.2 kidney
-
 Homo sapiens
-
7.6.2.2 liver
-
 Homo sapiens
-
7.6.2.2 mammary gland
-
 Homo sapiens
-
7.6.2.2 placenta
-
 Homo sapiens
-
7.6.2.2 renal proximal tubule epithelial cell
-
 Homo sapiens
-
7.6.2.2 syncytiotrophoblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.2 ATP + H2O + 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine[side 1]
-
 Homo sapiens ADP + phosphate + 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine[side 2]
-
 ?
7.6.2.2 ATP + H2O + cimetidine[side 1]
-
 Homo sapiens ADP + phosphate + cimetidine[side 2]
-
 ?
7.6.2.2 ATP + H2O + daunomycin[side 1]
-
 Homo sapiens ADP + phosphate + daunomycin[side 2]
-
 ?
7.6.2.2 ATP + H2O + daunorubicin[side 1]
-
 Homo sapiens ADP + phosphate + daunorubicin[side 2]
-
 ?
7.6.2.2 ATP + H2O + doxorubicin[side 1]
-
 Homo sapiens ADP + phosphate + doxorubicin[side 2]
-
 ?
7.6.2.2 ATP + H2O + Hoechst 33342[side 1]
-
 Homo sapiens ADP + phosphate + Hoechst 33342[side 2]
-
 ?
7.6.2.2 ATP + H2O + lyso-tracker green[side 1]
-
 Homo sapiens ADP + phosphate + lyso-tracker green[side 2]
-
 ?
7.6.2.2 ATP + H2O + methotrexate[side 1]
-
 Homo sapiens ADP + phosphate + methotrexate[side 2]
-
 ?
7.6.2.2 ATP + H2O + mitoxantrone[side 1]
-
 Homo sapiens ADP + phosphate + mitoxantrone[side 2]
-
 ?
7.6.2.2 ATP + H2O + prazosin[side 1]
-
 Homo sapiens ADP + phosphate + prazosin[side 2]
-
 ?
7.6.2.2 ATP + H2O + rhodamine 123[side 1]
-
 Homo sapiens ADP + phosphate + rhodamine 123[side 2]
-
 ?
7.6.2.2 ATP + H2O + riboflavin[side 1]
-
 Homo sapiens ADP + phosphate + riboflavin[side 2]
-
 ?
7.6.2.2 ATP + H2O + topotecan[side 1]
-
 Homo sapiens ADP + phosphate + topotecan[side 2]
-
 ?
7.6.2.2 ATP + H2O + xenobiotic[side 1]
-
 Homo sapiens ADP + phosphate + xenobiotic[side 2]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.6.2.2 ABCG2
-
 Homo sapiens
7.6.2.2 breast cancer resistance protein
-
 Homo sapiens
7.6.2.2 multidrug transporter
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
7.6.2.2 physiological function the localization of enzyme ABCG2 can play a vital role in limiting absorption (in the small intestine), mediating distribution (e.g. in the blood-brain and blood-placental barriers) and facilitating elimination and excretion (in the liver and kidney) of drugs or xenobiotics Homo sapiens