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Literature summary extracted from
- Protein disulfide isomerases Redox connections in and out of the endoplasmic reticulum (2017), Arch. Biochem. Biophys., 617, 106-119 .
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.4.1 | CCF642 | - |
Homo sapiens | |
| 5.3.4.1 | LOC14 | - |
Homo sapiens |  |
| 5.3.4.1 | quercetin-3-rutinoside | - |
Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 5.3.4.1 | endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.4.1 | beta-actin | Homo sapiens | - |
? | - |
? | |
| 5.3.4.1 | integrin alphaIIbbeta3 | Homo sapiens | - |
? | - |
? | |
| 5.3.4.1 | integrin alphaMb2 | Homo sapiens | - |
? | - |
? | |
| 5.3.4.1 | integrin alphaVb3 | Homo sapiens | - |
? | - |
? | |
| 5.3.4.1 | integrin alphaVbeta3 | Homo sapiens | - |
? | - |
? | |
| 5.3.4.1 | tissue factor | Homo sapiens | - |
? | - |
? | |
| 5.3.4.1 | transforming growth factor-beta1 | Homo sapiens | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.4.1 | Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.4.1 | beta-actin | - |
Homo sapiens | ? | - |
? | |
| 5.3.4.1 | integrin alphaIIbbeta3 | - |
Homo sapiens | ? | - |
? | |
| 5.3.4.1 | integrin alphaMb2 | - |
Homo sapiens | ? | - |
? | |
| 5.3.4.1 | integrin alphaVb3 | - |
Homo sapiens | ? | - |
? | |
| 5.3.4.1 | integrin alphaVbeta3 | - |
Homo sapiens | ? | - |
? | |
| 5.3.4.1 | tissue factor | - |
Homo sapiens | ? | - |
? | |
| 5.3.4.1 | transforming growth factor-beta1 | - |
Homo sapiens | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 5.3.4.1 | ? | x * 55000, SDS-PAGE | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.3.4.1 | PDIA1 | - |
Homo sapiens |
| 5.3.4.1 | protein disulfide isomerase | - |
Homo sapiens |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 5.3.4.1 | physiological function | isoform PDIA1 is required for agonist-triggered Nox NADPH oxidase activation and cell migration in vascular cells and macrophages. The enzyme also plays role in cytoskeleton organization | Homo sapiens |
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Release 2023.1 (January 2023)
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