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Literature summary extracted from

  • Zhu, W.; Liu, Y.
    Ring contraction catalyzed by the metal-dependent radical SAM enzyme 7-carboxy-7-deazaguanine synthase from B. multivorans. theoretical insights into the reaction mechanism and the influence of metal ions (2015), ACS Catal., 5, 3953-3965 .
No PubMed abstract available

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.3.99.3 Mg2+ dependent on Burkholderia multivorans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.3.99.3 6-carboxy-5,6,7,8-tetrahydropterin Burkholderia multivorans
-
 7-carboxy-7-carbaguanine + NH3
-
 ?
4.3.99.3 6-carboxy-5,6,7,8-tetrahydropterin Burkholderia multivorans ATCC 17616
-
 7-carboxy-7-carbaguanine + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.3.99.3 Burkholderia multivorans A0A0H3KB22
-
-
4.3.99.3 Burkholderia multivorans ATCC 17616 A0A0H3KB22
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.99.3 6-carboxy-5,6,7,8-tetrahydropterin
-
 Burkholderia multivorans 7-carboxy-7-carbaguanine + NH3
-
 ?
4.3.99.3 6-carboxy-5,6,7,8-tetrahydropterin the key ring-contraction step involves a bridged intermediate rather than a ring-opening one. For the QueE-Mg2+ system, the elimination of ammonia is calculated to be rate limiting, determined by investigation at an atomistic level by using the combined quantum mechanics and molecular mechanics method Burkholderia multivorans 7-carboxy-7-carbaguanine + NH3
-
 ?
4.3.99.3 6-carboxy-5,6,7,8-tetrahydropterin
-
 Burkholderia multivorans ATCC 17616 7-carboxy-7-carbaguanine + NH3
-
 ?
4.3.99.3 6-carboxy-5,6,7,8-tetrahydropterin the key ring-contraction step involves a bridged intermediate rather than a ring-opening one. For the QueE-Mg2+ system, the elimination of ammonia is calculated to be rate limiting, determined by investigation at an atomistic level by using the combined quantum mechanics and molecular mechanics method Burkholderia multivorans ATCC 17616 7-carboxy-7-carbaguanine + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.3.99.3 queE
-
 Burkholderia multivorans

Cofactor

EC Number Cofactor Comment Organism Structure
4.3.99.3 S-adenosyl-L-methionine S-adenosyl-L-methionine-dependent radical enzyme Burkholderia multivorans