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Literature summary extracted from

  • Xiao, C.; Liu, Y.; Xie, C.; Tu, W.; Xia, Y.; Costa, M.; Zhou, X.
    Cadmium induces histone H3 lysine methylation by inhibiting histone demethylase activity (2015), Toxicol. Sci., 145, 80-89 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.11.65 ascorbate required Homo sapiens
1.14.11.67 ascorbate required Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.11.65 Cd2+ at 0.001-0.005 mM, cadmium induces histone H3 lysine methylation by inhibiting histone demethylase activity on H3K4 and H3K9. Cadmium increases global histone H3 methylation, H3K4me3 and H3K9me2, by inhibiting the activities of histone demethylases, and aberrant histone methylation that occurs early (48 h) and at 4 weeks is associated with cadmium-induced transformation of BEAS-2B cells at the early stage Homo sapiens
1.14.11.67 Cd2+ at 0.001-0.005 mM, cadmium increases global histone H3 methylation, H3K4me3 and H3K9me2, by inhibiting the activities of histone demethylases, and aberrant histone methylation that occurs early (48 h) and at 4 weeks is associated with cadmium-induced transformation of BEAS-2B cells at the early stage; at 0.001-0.005 mM, cadmium induces histone H3 lysine methylation by inhibiting histone demethylase activity on H3K4 and H3K9. Cadmium increases global histone H3 methylation, H3K4me3 and H3K9me2, by inhibiting the activities of histone demethylases, and aberrant histone methylation that occurs early (48 h) and at 4 weeks is associated with cadmium-induced transformation of BEAS-2B cells at the early stage Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.11.65 chromatin
-
 Homo sapiens 785
-
1.14.11.65 nucleus
-
 Homo sapiens 5634
-
1.14.11.67 chromatin
-
 Homo sapiens 785
-
1.14.11.67 nucleus
-
 Homo sapiens 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.11.65 Fe2+ dependent on Homo sapiens
1.14.11.67 Fe2+ dependent on Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.65 [histone H3]-N6,N6-dimethyl-L-lysine 9 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-N6-methyl-L-lysine 9 + succinate + formaldehyde + CO2
-
 ?
1.14.11.65 [histone H3]-N6-methyl-L-lysine 9 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-L-lysine 9 + succinate + formaldehyde + CO2
-
 ?
1.14.11.67 histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 Homo sapiens
-
 histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
-
 ?
1.14.11.67 [histone H3]-N6,N6,N6-trimethyl-L-lysine 4 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-N6,N6-dimethyl-L-lysine 4 + succinate + formaldehyde + CO2
-
 ?
1.14.11.67 [histone H3]-N6,N6-drimethyl-L-lysine 4 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-N6-methyl-L-lysine 4 + succinate + formaldehyde + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.65 Homo sapiens Q9Y4C1
-
-
1.14.11.67 Homo sapiens P29375
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.65 BEAS-2B cell
-
 Homo sapiens
-
1.14.11.67 BEAS-2B cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.65 [histone H3]-N6,N6-dimethyl-L-lysine 9 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-N6-methyl-L-lysine 9 + succinate + formaldehyde + CO2
-
 ?
1.14.11.65 [histone H3]-N6-methyl-L-lysine 9 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-L-lysine 9 + succinate + formaldehyde + CO2
-
 ?
1.14.11.67 histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
-
 Homo sapiens histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
-
 ?
1.14.11.67 [histone H3]-N6,N6,N6-trimethyl-L-lysine 4 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-N6,N6-dimethyl-L-lysine 4 + succinate + formaldehyde + CO2
-
 ?
1.14.11.67 [histone H3]-N6,N6-drimethyl-L-lysine 4 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-N6-methyl-L-lysine 4 + succinate + formaldehyde + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.65 H3K9 demethylase
-
 Homo sapiens
1.14.11.65 Kdm3a
-
 Homo sapiens
1.14.11.65 lysine-specific demethylase 3A
-
 Homo sapiens
1.14.11.67 H3K4 demethylase
-
 Homo sapiens
1.14.11.67 H3K4 demethylase lysine-specific demethylase 5A
-
 Homo sapiens
1.14.11.67 KDM5A
-
 Homo sapiens
1.14.11.67 lysine-specific demethylase 5A
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.11.65 37
-
 assay at Homo sapiens
1.14.11.67 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.11.65 8
-
 assay at Homo sapiens
1.14.11.67 8
-
 assay at Homo sapiens