EC Number | Cloned (Comment) | Organism |
---|---|---|
1.17.1.8 | expression in Escherichia coli as His-tagged construct | Trichormus variabilis |
4.3.3.7 | expression in Escherichia coli as His-tagged construct | Trichormus variabilis |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
1.17.1.8 | crystal structure is determined at 1.92 A | Trichormus variabilis |
4.3.3.7 | crystal structure is determined at 1.92 A | Trichormus variabilis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.17.1.8 | (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate | when NADPH is employed as the cofactor | Trichormus variabilis | |
4.3.3.7 | (S)-lysine | - |
Trichormus variabilis |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.17.1.8 | 0.31 | - |
NADH | 30°C, pH not specified in the publication | Trichormus variabilis | |
1.17.1.8 | 3.6 | - |
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate | 30°C, pH not specified in the publication | Trichormus variabilis | |
4.3.3.7 | 0.14 | - |
L-aspartate-4-semialdehyde | 30°C, pH not specified in the publication | Trichormus variabilis | |
4.3.3.7 | 0.41 | - |
pyruvate | 30°C, pH not specified in the publication | Trichormus variabilis |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.17.1.8 | 139000 | - |
analytical ultracentrifugation | Trichormus variabilis |
4.3.3.7 | 147000 | - |
analytical ultracentrifugation | Trichormus variabilis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.17.1.8 | Trichormus variabilis | Q3M723 | - |
- |
4.3.3.7 | Trichormus variabilis | Q3MFY8 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
4.3.3.7 | - |
Trichormus variabilis |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.17.1.8 | (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+ | - |
Trichormus variabilis | (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD+ + H2O | - |
? | |
4.3.3.7 | pyruvate + L-aspartate-4-semialdehyde | - |
Trichormus variabilis | (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.17.1.8 | homotetramer | - |
Trichormus variabilis |
4.3.3.7 | homotetramer | - |
Trichormus variabilis |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.17.1.8 | DHDPR | - |
Trichormus variabilis |
4.3.3.7 | DHDPS | - |
Trichormus variabilis |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.17.1.8 | 30 | - |
assay at | Trichormus variabilis |
4.3.3.7 | 30 | - |
assay at | Trichormus variabilis |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
4.3.3.7 | 0.068 | - |
30°C, pH not specified in the publication | Trichormus variabilis | (S)-lysine |