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Literature summary extracted from

  • Omi, T.; Nakazawa, S.; Udagawa, C.; Tada, N.; Ochiai, K.; Chong, Y.H.; Kato, Y.; Mitsui, H.; Gin, A.; Oda, H.; Azakami, D.; Tamura, K.; Sako, T.; Inagaki, T.; Sakamoto, A.; Tsutsui, T.; Bonkobara, M.; Tsuchida, S.; Ikemoto, S.
    Molecular characterization of the cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) gene associated with the feline AB blood group system (2016), PLoS ONE, 11, e0165000 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.18.2 gene CMAH, genotyping, genetic structure, and phylogenetic analysis. Haplotype inference, which is focused on non-synonymous single-nucleotide polymorphisms reveals that eight haplotypes carry one to four mutations in CMAH, and all cats with type B (n = 34) and AB (n = 2) blood carry two alleles derived from the mutated CMAH gene Felis catus

Protein Variants

EC Number Protein Variants Comment Organism
1.14.18.2 D535N naturally occuring mutation, genotyping, overview Felis catus
1.14.18.2 E109D naturally occuring mutation, genotyping, overview Felis catus
1.14.18.2 G60V naturally occuring mutation, genotyping, overview Felis catus
1.14.18.2 I63V naturally occuring mutation, genotyping, overview Felis catus
1.14.18.2 P122S naturally occuring mutation, genotyping, overview Felis catus
1.14.18.2 R47C naturally occuring mutation, genotyping, overview Felis catus
1.14.18.2 V48M naturally occuring mutation, genotyping, overview Felis catus
1.14.18.2 Y90N naturally occuring mutation, genotyping, overview Felis catus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.18.2 cell membrane
-
 Felis catus
-
-
1.14.18.2 cell surface
-
 Felis catus 9986
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.18.2 CMP-N-acetylneuraminate + 2 ferrocytochrome b5 + O2 + 2 H+ Felis catus
-
 CMP-N-glycoloylneuraminate + 2 ferricytochrome b5 + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.2 Felis catus A6Y8N2
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.2 erythrocyte
-
 Felis catus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.2 CMP-N-acetylneuraminate + 2 ferrocytochrome b5 + O2 + 2 H+
-
 Felis catus CMP-N-glycoloylneuraminate + 2 ferricytochrome b5 + H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.18.2 cytochrome b5
-
 Felis catus

General Information

EC Number General Information Comment Organism
1.14.18.2 evolution gene CMAH, genotyping, genetic structure, and phylogenetic analysis. Haplotype inference, which is focused on non-synonymous single-nucleotide polymorphisms reveals that eight haplotypes carry one to four mutations in CMAH, and all cats with type B (n = 34) and AB (n = 2) blood carry two alleles derived from the mutated CMAH gene Felis catus
1.14.18.2 physiological function the cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) gene is associated with the feline AB blood group system, type A and type B antigens are Neu5Gc and Neu5Ac, respectively. Distribution of AB blood group antigens, CMAH gene structure, mutation, diplotypes, and haplotypes of the cat CMAH genes, overview. The feline AB blood group system consists of A and B antigens and contains blood group type A (type A), blood group type B (type B), and the rare blood group type AB (type AB). Type A erythrocytes express N-glycolylneuraminic acid (Neu5Gc) and type B erythrocytes express N-acetylneuraminic acid (Neu5Ac). The enzyme cytidinemonophosphate-N-acetylneuraminic acid hydroxylase synthesizes Neu5Ac to Neu5Gc. type AB erythrocytes have less Neu5Ac than type A erythrocytes and less Neu5Gc than type B erythrocytes Felis catus