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Literature summary extracted from

  • Yin, C.; Park, J.; Gang, D.; Hulbert, S.
    Characterization of a tryptophan 2-monooxygenase gene from Puccinia graminis f. sp. tritici involved in auxin biosynthesis and rust pathogenicity (2014), Mol. Plant Microbe Interact., 27, 227-235 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.12.3 gene PGTG_11658 or Pgt-IaaM, transgenic expression of gene Pgt-IaaM in Arabidopsis thaliana haustoria causes a typical auxin expression phenotype and promotes susceptibility to the bacterial pathogen Pseudomonas syringae pv. tomato DC3000, transgenic expression of gene Pgt-IaaM in Triticum aestivum leaves, phenotypes, overview. Silencing of Pgt-IaaM by wheat host-induced gene silencing reduces the pathogenicity of Puccinia graminis. Expression of Pgt-IaaM in Arabidopsis thaliana displays pleiotropic auxin-related phenotypes Puccinia graminis f. sp. tritici

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.12.3 L-tryptophan + O2 Puccinia graminis f. sp. tritici
-
 (indol-3-yl)acetamide + CO2 + H2O
-
 ?
1.13.12.3 L-tryptophan + O2 Puccinia graminis f. sp. tritici CRL 75-36-700-3
-
 (indol-3-yl)acetamide + CO2 + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.12.3 Puccinia graminis f. sp. tritici E3KNM7
-
-
1.13.12.3 Puccinia graminis f. sp. tritici CRL 75-36-700-3 E3KNM7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.12.3 L-tryptophan + O2
-
 Puccinia graminis f. sp. tritici (indol-3-yl)acetamide + CO2 + H2O
-
 ?
1.13.12.3 L-tryptophan + O2
-
 Puccinia graminis f. sp. tritici CRL 75-36-700-3 (indol-3-yl)acetamide + CO2 + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.12.3 Pgt-IaaM
-
 Puccinia graminis f. sp. tritici
1.13.12.3 PGTG_11658
-
 Puccinia graminis f. sp. tritici

General Information

EC Number General Information Comment Organism
1.13.12.3 malfunction transient silencing of the tryptophan 2-monooxygenase-encoding gene iaaM in infected wheat plants indicates that it is required for full pathogenicity Puccinia graminis f. sp. tritici
1.13.12.3 physiological function tryptophan 2-monooxygenase from Puccinia graminis f. sp. tritici produces the auxin precursor indole-3-acetamide (IAM) and is involved in auxin biosynthesis and rust pathogenicity. Auxin acts as a regulator of plant growth and development but its production can also affect plant–microbe interactions. Expression of Pgt-IaaM in Arabidopsis thaliana haustoria causes a typical auxin expression phenotype and promotes susceptibility to the bacterial pathogen Pseudomonas syringae pv. tomato DC3000 Puccinia graminis f. sp. tritici