Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Wang, B.; Wen, X.; Xi, Z.
    Molecular simulations bring new insights into protoporphyrinogen IX oxidase/protoporphyrinogen IX interaction modes (2016), Mol. Inform., 35, 476-482 .
    View publication on PubMed

Application

EC Number Application Comment Organism
1.3.3.4 drug development enzyme PPO is an excellent target for commercial herbicides Nicotiana tabacum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.3.4 mitochondrion
-
 Nicotiana tabacum 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.3.4 protoporphyrinogen IX + 3 O2 Nicotiana tabacum
-
 protoporphyrin IX + 3 H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.3.4 Nicotiana tabacum O24164
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.3.3.4 protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2 reaction scheme involving FAD, overview Nicotiana tabacum
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.3.4 protoporphyrinogen IX + 3 O2
-
 Nicotiana tabacum protoporphyrin IX + 3 H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.3.4 mtPPO
-
 Nicotiana tabacum
1.3.3.4 PPO
-
 Nicotiana tabacum
1.3.3.4 protoporphyrinogen IX oxidase
-
 Nicotiana tabacum

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.3.4 FAD modeling of binding structure, overview Nicotiana tabacum

General Information

EC Number General Information Comment Organism
1.3.3.4 malfunction deficient activity of PPO causes the accumulation and nonenzymatic oxidation of protogen IX leading to cellular damage. For green plants, inhibition of PPO leads to the rapid bleaching and desiccation of photosynthetically active parts of the plant Nicotiana tabacum
1.3.3.4 additional information analysis of binding mode of protogen IX in the Nicotiana tabacum protoporphyrinogen IX oxidase (mtPPO) by performing a computational docking followed by molecular simulations, quantum mechanics calculations, and an integrated analysis, overview. Several potential key residues, e.g. Thr70, Arg233, Ser235, Ser474 and Lys477, are identified. Residue Arg98 is necessary for binding of protogen IX. Comparison of the Nicotiana tabacum enzyme with the human enzyme. Modeling of ligand binding structures Nicotiana tabacum
1.3.3.4 physiological function protoporphyrinogen IX oxidase catalyzes the oxidation of protoporphyrinogen IX (protogen IX) to protoporphyrin IX (proto IX) in the haem/chlorophyll biosynthetic pathway Nicotiana tabacum