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Literature summary extracted from

  • Alvarez-Rueda, N.; Fleury, A.; Loge, C.; Pagniez, F.; Robert, E.; Morio, F.; Le Pape, P.
    The amino acid substitution N136Y in Candida albicans sterol 14alpha-demethylase is involved in fluconazole resistance (2016), Med. Mycol., 54, 764-775 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.154 expression of mutant and wild-type enzymes in Pichia pastoris Candida albicans

Protein Variants

EC Number Protein Variants Comment Organism
1.14.14.154 N136Y N136Y transformants show a reduced in vitro susceptibility to fluconazole compared to wild-type controls. The amino acid substitution N136Y in Candida albicans sterol 14alpha-demethylase is involved in fluconazole resistance Candida albicans

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.154 fluconazole N136Y transformants show a reduced in vitro susceptibility to fluconazole compared to wild-type controls. The amino acid substitution N136Y in Candida albicans sterol 14alpha-demethylase is involved in fluconazole resistance Candida albicans

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.154 Candida albicans C8XRD8
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.154 lanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Candida albicans ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.154 ERG11
-
 Candida albicans

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.154 NADPH-hemoprotein reductase A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._ Candida albicans