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Literature summary extracted from

  • Azam, S.; Abbasi, S.; Akhtar, A.; Mirza, M.
    Comparative modeling and molecular docking studies of D-alanine D-alanine ligase a target of antibacterial drugs (2014), Med. Chem. Res., 23, 4108-4137 .
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.2.4 gene ddl, recombinant expression Streptococcus sanguinis

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.4 (1E,3Z)-N-(2-carbamimidamidoethyl)-4-(pyridin-3-yl)buta-1,3-diene-1-sulfonamide
-
 Streptococcus sanguinis
6.3.2.4 (2-aminoethyl)phosphonic acid
-
 Streptococcus sanguinis
6.3.2.4 (2E)-3-amino-2-[(E)-(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-3-sulfanylprop-2-enenitrile
-
 Streptococcus sanguinis
6.3.2.4 (2R)-2-aminopropanoyl hydrogen (2-hydroxybutanoyl)phosphonate
-
 Streptococcus sanguinis
6.3.2.4 (2R)-2-[[(1-aminoethyl)(hydroxy)phosphoryl]methyl]nonanoic acid
-
 Streptococcus sanguinis
6.3.2.4 (2S)-2-amino-4-[(3S)-3-hydroxy-2-oxoazetidin-3-yl]butanoic acid
-
 Streptococcus sanguinis
6.3.2.4 (2Z)-2-cyano-3-hydroxy-N-(2,4,6-trimethylphenyl)but-2-enamide
-
 Streptococcus sanguinis
6.3.2.4 (2Z)-2-cyano-3-hydroxy-N-[2-methyl-3,6-bis(trifluoromethyl)phenyl]but-2-enamide
-
 Streptococcus sanguinis
6.3.2.4 (2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethoxy)phenyl]but-2-enamide
-
 Streptococcus sanguinis
6.3.2.4 (2Z)-2-cyano-N-(2,5-dibromophenyl)-3-hydroxybut-2-enamide
-
 Streptococcus sanguinis
6.3.2.4 (2Z)-2-cyano-N-(2,6-dimethylphenyl)-3-hydroxybut-2-enamide
-
 Streptococcus sanguinis
6.3.2.4 (2Z)-N-(2-chloro-6-methylphenyl)-2-cyano-3-hydroxybut-2-enamide
-
 Streptococcus sanguinis
6.3.2.4 (2Z)-N-(2-chloro-6-methylphenyl)-2-ethynyl-3-hydroxybut-2-enamide
-
 Streptococcus sanguinis
6.3.2.4 (3Z)-4-cyano-5-(3,6-dibromo-2-methylanilino)-3-hydroxy-5-oxopent-3-enoic acid
-
 Streptococcus sanguinis
6.3.2.4 (4R)-4-amino-1,2-oxazolidin-3-one
-
 Streptococcus sanguinis
6.3.2.4 (E)-2-[[(chloromethyl)amino]acetyl]-N-[(pyridin-2-yl)methyl]diazene-1-carboxamide
-
 Streptococcus sanguinis
6.3.2.4 (E)-N1,N2-bis(2-chloroethyl)diazene-1,2-dicarboxamide
-
 Streptococcus sanguinis
6.3.2.4 (E)-N1,N2-bis[(pyridin-3-yl)methyl]diazene-1,2-dicarboxamide
-
 Streptococcus sanguinis
6.3.2.4 (E)-N1-(2-chloroethyl)-N2-(4-methylphenyl)diazene-1,2-dicarboxamide
-
 Streptococcus sanguinis
6.3.2.4 (E)-N1-(2-chloroethyl)-N2-[(pyridin-4-yl)methyl]diazene-1,2-dicarboxamide
-
 Streptococcus sanguinis
6.3.2.4 (E)-N1-(3-chlorophenyl)-N2-[(pyridin-3-yl)methyl]diazene-1,2-dicarboxamide
-
 Streptococcus sanguinis
6.3.2.4 (E)-N1-(3-chlorophenyl)-N2-[(pyridin-4-yl)methyl]diazene-1,2-dicarboxamide
-
 Streptococcus sanguinis
6.3.2.4 (E)-N1-(4-fluorophenyl)-N2-[(pyridin-4-yl)methyl]diazene-1,2-dicarboxamide
-
 Streptococcus sanguinis
6.3.2.4 (E)-N1-cyclohexyl-N2-[(pyridin-2-yl)methyl]diazene-1,2-dicarboxamide
-
 Streptococcus sanguinis
6.3.2.4 (E)-N1-cyclohexyl-N2-[(pyridin-4-yl)methyl]diazene-1,2-dicarboxamide
-
 Streptococcus sanguinis
6.3.2.4 (E)-N1-phenyl-N2-[(pyridin-3-yl)methyl]diazene-1,2-dicarboxamide
-
 Streptococcus sanguinis
6.3.2.4 (E)-N1-phenyl-N2-[(pyridin-4-yl)methyl]diazene-1,2-dicarboxamide
-
 Streptococcus sanguinis
6.3.2.4 (E)-N1-[4-(butan-2-yl)phenyl]-N2-(2-chloroethyl)diazene-1,2-dicarboxamide
-
 Streptococcus sanguinis
6.3.2.4 1-[(4-fluorocyclohexane-1-sulfonyl)amino]-3-(morpholin-4-yl)propan-2-yl dihydrogen phosphate
-
 Streptococcus sanguinis
6.3.2.4 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one
-
 Streptococcus sanguinis
6.3.2.4 2-(3-methylmorpholin-4-yl)-8-phenyl-2,3-dihydro-4H-1-benzopyran-4-one
-
 Streptococcus sanguinis
6.3.2.4 2-([(1R)-1-aminoethyl](hydroxy)phosphoryl]methyl)octanoic acid
-
 Streptococcus sanguinis
6.3.2.4 2-amino-4-(3,4,5-trihydroxyphenyl)but-1-ene-1,1,3-tricarbonitrile
-
 Streptococcus sanguinis
6.3.2.4 2-cyano-3-hydroxy-N-[2-methyl-4-(trifluoromethyl)phenyl]butanamide
-
 Streptococcus sanguinis
6.3.2.4 2-hydroxy-N-(2,4,6-trimethylphenyl)benzamide
-
 Streptococcus sanguinis
6.3.2.4 2-[[(1-aminoethyl)(hydroxy)phosphoryl]methyl]nonanoic acid
-
 Streptococcus sanguinis
6.3.2.4 2-[[6-(benzylamino)-9-methyl-9H-purin-2-yl]amino]ethan-1-ol
-
 Streptococcus sanguinis
6.3.2.4 3-chloro-2,2-dimethyl-N-[4-(trifluoromethyl)cyclohexyl]propanamide
-
 Streptococcus sanguinis
6.3.2.4 3-[[(1S)-1-aminoethyl](hydroxy)phosphoryl]-2-methylpropanoic acid
-
 Streptococcus sanguinis
6.3.2.4 4-chloro-3,3-dimethyl-N-[4-(trifluoromethyl)phenyl]butanamide
-
 Streptococcus sanguinis
6.3.2.4 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol
-
 Streptococcus sanguinis
6.3.2.4 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
-
 Streptococcus sanguinis
6.3.2.4 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
-
 Streptococcus sanguinis
6.3.2.4 6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
-
 Streptococcus sanguinis
6.3.2.4 6-(2,6-dichlorophenyl)-N2-[3-(dimethylamino)propyl]pyrido[2,3-d]pyrimidine-2,7-diamine
-
 Streptococcus sanguinis
6.3.2.4 6-(2,6-dichlorophenyl)-N2-[3-(morpholin-4-yl)propyl]pyrido[2,3-d]pyrimidine-2,7-diamine
-
 Streptococcus sanguinis
6.3.2.4 6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
-
 Streptococcus sanguinis
6.3.2.4 6-(2,6-difluorophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
-
 Streptococcus sanguinis
6.3.2.4 6-(2-chloro-6-fluorophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
-
 Streptococcus sanguinis
6.3.2.4 6-(3,5-dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
-
 Streptococcus sanguinis
6.3.2.4 6-(3,5-dimethoxyphenyl)-N2-[3-(morpholin-4-yl)propyl]pyrido[2,3-d]pyrimidine-2,7-diamine
-
 Streptococcus sanguinis
6.3.2.4 6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
-
 Streptococcus sanguinis
6.3.2.4 6-(3,5-dimethylphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
-
 Streptococcus sanguinis
6.3.2.4 6-phenylpyrido[2,3-d]pyrimidine-2,7-diamine
-
 Streptococcus sanguinis
6.3.2.4 6-[3,5-bis(trifluoromethyl)phenyl]pyrido[2,3-d]pyrimidine-2,7-diamine
-
 Streptococcus sanguinis
6.3.2.4 D-alanyl-D-alanine
-
 Streptococcus sanguinis
6.3.2.4 glycine
-
 Streptococcus sanguinis
6.3.2.4 glycylglycine
-
 Streptococcus sanguinis
6.3.2.4 additional information inhibitor docking and molecular structure modeling, overview Streptococcus sanguinis
6.3.2.4 N-(2,5-dibromophenyl)-2-oxopropanamide
-
 Streptococcus sanguinis
6.3.2.4 N-(2,6-dimethylphenyl)-2-hydroxybenzamide
-
 Streptococcus sanguinis
6.3.2.4 N-(2-amino-6-phenylpyrido[2,3-d]pyrimidin-7-yl)-N'-tert-butylurea
-
 Streptococcus sanguinis
6.3.2.4 N-(3,6-dibromo-2-methylphenyl)-2-hydroxybenzamide
-
 Streptococcus sanguinis
6.3.2.4 N-tert-butyl-N'-[6-(2,6-dichlorophenyl)-2-[[3-(morpholin-4-yl)propyl]amino]pyrido[2,3-d]pyrimidin-7-yl]urea
-
 Streptococcus sanguinis
6.3.2.4 N-tert-butyl-N'-[6-(3,5-dimethoxyphenyl)-2-[[3-(morpholin-4-yl)propyl]amino]pyrido[2,3-d]pyrimidin-7-yl]urea
-
 Streptococcus sanguinis
6.3.2.4 N-[(2S)-1-[(dihydroxyphosphanyl)oxy]-1-oxopropan-2-yl]-D-alaninamide
-
 Streptococcus sanguinis
6.3.2.4 N-[2-amino-6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-tert-butylurea
-
 Streptococcus sanguinis
6.3.2.4 N-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-tert-butylurea
-
 Streptococcus sanguinis
6.3.2.4 N-[2-amino-6-(2,6-difluorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-tert-butylurea
-
 Streptococcus sanguinis
6.3.2.4 N-[2-amino-6-(2-chloro-6-fluorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-tert-butylurea
-
 Streptococcus sanguinis
6.3.2.4 N-[2-amino-6-(3,5-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-tert-butylurea
-
 Streptococcus sanguinis
6.3.2.4 N-[2-amino-6-(3,5-difluorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-tert-butylurea
-
 Streptococcus sanguinis
6.3.2.4 N-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-tert-butylurea
-
 Streptococcus sanguinis
6.3.2.4 N-[2-amino-6-[3,5-bis(trifluoromethyl)phenyl]pyrido[2,3-d]pyrimidin-7-yl]-N'-tert-butylurea
-
 Streptococcus sanguinis
6.3.2.4 N2-(3-aminopropyl)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
-
 Streptococcus sanguinis
6.3.2.4 P-(aminomethyl)phosphonamidic acid
-
 Streptococcus sanguinis
6.3.2.4 [(1R)-1-aminoethyl]phosphinic acid
-
 Streptococcus sanguinis
6.3.2.4 [(1R)-1-aminoethyl]phosphonic acid
-
 Streptococcus sanguinis

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.4 Streptococcus sanguinis A3CLS3
-
-
6.3.2.4 Streptococcus sanguinis SK36 A3CLS3
-
-

Subunits

EC Number Subunits Comment Organism
6.3.2.4 More three-dimensional enzyme structure and structure homology modeling using the Ddl structure mdoel of Streptococcus mutans (SmDdl) as template, PDB ID 3K3P, overview Streptococcus sanguinis

Synonyms

EC Number Synonyms Comment Organism
6.3.2.4 D-Alanine:D-alanine ligase
-
 Streptococcus sanguinis
6.3.2.4 Ddl
-
 Streptococcus sanguinis
6.3.2.4 SsDdl
-
 Streptococcus sanguinis

General Information

EC Number General Information Comment Organism
6.3.2.4 additional information comparative molecular modeling approach for SsDdl, enzyme structure homology modeling using the Ddl structure mdoel of Streptococcus mutans (SmDdl) as template, PDB ID 3K3P, overview Streptococcus sanguinis