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Literature summary extracted from
- DELTA9-Tetrahydrocannabinolic acid synthase The application of a plant secondary metabolite enzyme in biocatalytic chemical synthesis (2016), J. Biotechnol., 233, 42-48 .
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.21.3.7 | BSA | the addition of BSA has a slightly positive effect on the activity of the enzyme | Cannabis sativa |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.21.3.7 | expressed in Pichia pastoris KM71 KE1 cells | Cannabis sativa |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.21.3.7 | cannabigerolate | substrate inhibition | Cannabis sativa |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.21.3.7 | 0.0084 | - |
cannabigerolate | at pH 5.0 and 30°C | Cannabis sativa | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.21.3.7 | cannabigerolate + O2 | Cannabis sativa | - |
DELTA9-tetrahydrocannabinolate + H2O2 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.21.3.7 | Cannabis sativa | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.21.3.7 | cannabigerolate + O2 | - |
Cannabis sativa | DELTA9-tetrahydrocannabinolate + H2O2 | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.21.3.7 | ? | x * 59000, SDS-PAGE | Cannabis sativa |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.21.3.7 | DELTA9-tetrahydrocannabinolic acid synthase | - |
Cannabis sativa |
| 1.21.3.7 | THCAS | - |
Cannabis sativa |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.21.3.7 | 0.308 | - |
cannabigerolate | at pH 5.0 and 30°C | Cannabis sativa | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.21.3.7 | FAD | - |
Cannabis sativa | |
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