EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.17.3.2 | 3,4-dihydroxyphenyl dodecanoate | sigmoidal inhibition of superoxide anion formation | Bos taurus | |
1.17.3.2 | 3,4-dihydroxyphenyl octanoate | - |
Bos taurus | |
1.17.3.2 | butyl caffeate | competitive inhibition of urate and superoxide anion formation | Bos taurus | |
1.17.3.2 | caffeic acid | competitive inhibition of urate and superoxide anion formation | Bos taurus | |
1.17.3.2 | decyl caffeate | competitive inhibition of urate and superoxide anion formation | Bos taurus | |
1.17.3.2 | heptyl caffeate | competitive inhibition of urate and superoxide anion formation | Bos taurus | |
1.17.3.2 | hexyl caffeate | competitive inhibition of urate and superoxide anion formation | Bos taurus | |
1.17.3.2 | methyl caffeate | competitive inhibition of urate and superoxide anion formation | Bos taurus | |
1.17.3.2 | additional information | alkyl caffeates are strong antioxidants and inhibitors of xanthine oxidase. Caffeic acid derivatives equally suppressed O2- generation, and the suppression is stronger than inhibition of xanthine oxidase. Suppression of O2- generation catalyzed by xanthine oxidase with caffeic acid derivatives is not due to enzyme inhibition or O2 - scavenging but due to the reduction of xanthine oxidase molecules. Alkyl caffeates are effective inhibitors of uric acid and O2- catalyzed by xanthine oxidase as well as antioxidants for edible oil | Bos taurus | |
1.17.3.2 | octyl protocatechuate | competitive inhibition of urate and superoxide anion formation | Bos taurus | |
1.17.3.2 | pentyl caffeate | competitive inhibition of urate and superoxide anion formation | Bos taurus | |
1.17.3.2 | propyl caffeate | competitive inhibition of urate and superoxide anion formation | Bos taurus | |
1.17.3.2 | propyl protocatechuate | sigmoidal inhibition of superoxide anion formation | Bos taurus | |
1.17.3.2 | protocatechuic acid | competitive inhibition of urate and superoxide anion formation | Bos taurus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.17.3.2 | Bos taurus | P80457 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.17.3.2 | commercial preparation | - |
Bos taurus | - |
1.17.3.2 | milk | - |
Bos taurus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.17.3.2 | additional information | scavenging activities of 1,1-diphenyl-2-picryhydrazyl (DPPH) radical and O2 generated with phenazine methosulfate (PMS) and NADH,overview | Bos taurus | ? | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.17.3.2 | 25 | - |
assay at, superoxid anion generation by xanthine oxidase | Bos taurus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.17.3.2 | 10 | - |
assay at, superoxide anion generation by xanthine oxidase | Bos taurus |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.17.3.2 | 0.0076 | - |
pH 10.0, 25°C, inhibition of urate formation | Bos taurus | heptyl caffeate | |
1.17.3.2 | 0.01 | - |
pH 10.0, 25°C, inhibition of urate formation | Bos taurus | decyl caffeate | |
1.17.3.2 | 0.01 | - |
pH 10.0, 25°C, inhibition of urate formation | Bos taurus | pentyl caffeate | |
1.17.3.2 | 0.0108 | - |
pH 10.0, 25°C, inhibition of urate formation | Bos taurus | hexyl caffeate | |
1.17.3.2 | 0.0115 | - |
above, pH 10.0, 25°C, inhibition of urate formation | Bos taurus | caffeic acid | |
1.17.3.2 | 0.0115 | - |
pH 10.0, 25°C, inhibition of urate formation | Bos taurus | propyl caffeate | |
1.17.3.2 | 0.012 | - |
pH 10.0, 25°C, inhibition of urate formation | Bos taurus | methyl caffeate | |
1.17.3.2 | 0.0125 | - |
pH 10.0, 25°C, inhibition of urate formation | Bos taurus | heptyl caffeate | |
1.17.3.2 | 0.0164 | - |
pH 10.0, 25°C, inhibition of urate formation | Bos taurus | decyl caffeate | |
1.17.3.2 | 0.018 | - |
pH 10.0, 25°C, inhibition of urate formation | Bos taurus | pentyl caffeate | |
1.17.3.2 | 0.019 | - |
pH 10.0, 25°C, inhibition of urate formation | Bos taurus | hexyl caffeate | |
1.17.3.2 | 0.022 | - |
above, pH 10.0, 25°C, inhibition of urate formation | Bos taurus | protocatechuic acid | |
1.17.3.2 | 0.026 | - |
pH 10.0, 25°C, inhibition of urate formation | Bos taurus | butyl caffeate | |
1.17.3.2 | 0.03 | - |
pH 10.0, 25°C, inhibition of urate formation | Bos taurus | propyl caffeate | |
1.17.3.2 | 0.0627 | - |
above, pH 10.0, 25°C, inhibition of urate formation | Bos taurus | propyl protocatechuate | |
1.17.3.2 | 0.082 | - |
above, pH 10.0, 25°C, inhibition of urate formation | Bos taurus | octyl protocatechuate | |
1.17.3.2 | 0.125 | - |
above, pH 10.0, 25°C, inhibition of urate formation | Bos taurus | protocatechuic acid | |
1.17.3.2 | 0.125 | - |
above, pH 10.0, 25°C, inhibition of urate formation | Bos taurus | octyl protocatechuate | |
1.17.3.2 | 0.125 | - |
above, pH 10.0, 25°C, inhibition of urate formation | Bos taurus | propyl protocatechuate | |
1.17.3.2 | 0.143 | - |
pH 10.0, 25°C, inhibition of urate formation | Bos taurus | methyl caffeate | |
1.17.3.2 | 0.2 | - |
above, pH 10.0, 25°C, inhibition of urate formation | Bos taurus | caffeic acid | |
1.17.3.2 | 0.2 | - |
above, pH 10.0, 25°C, inhibition of urate formation | Bos taurus | 3,4-dihydroxyphenyl dodecanoate | |
1.17.3.2 | 0.2 | - |
above, pH 10.0, 25°C, inhibition of urate formation | Bos taurus | 3,4-dihydroxyphenyl octanoate | |
1.17.3.2 | 92.5 | - |
above, pH 10.0, 25°C, inhibition of urate formation | Bos taurus | 3,4-dihydroxyphenyl dodecanoate | |
1.17.3.2 | 110 | - |
pH 10.0, 25°C, inhibition of urate formation | Bos taurus | butyl caffeate |