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Literature summary extracted from

  • Abrisqueta, M.; Sueren-Castillo, S.; Maestro, J.L.
    Insulin receptor-mediated nutritional signalling regulates juvenile hormone biosynthesis and vitellogenin production in the German cockroach (2014), Insect Biochem. Mol. Biol., 49, 14-23 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.127 gene CYP15A1, RT-PCR enzyme expression analysis Blattella germanica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.127 methyl (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2 Blattella germanica
-
 juvenile hormone III + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.127 Blattella germanica D6CJJ9
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.127 corpus allatum
-
 Blattella germanica
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.127 methyl (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
-
 Blattella germanica juvenile hormone III + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.127 CYP15A1
-
 Blattella germanica
1.14.14.127 CYP15A1 protein
-
 Blattella germanica

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.127 cytochrome P450
-
 Blattella germanica
1.14.14.127 NADPH-hemoprotein reductase A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._ Blattella germanica

Expression

EC Number Organism Comment Expression
1.14.14.127 Blattella germanica starving reduces the enzyme expression down

General Information

EC Number General Information Comment Organism
1.14.14.127 malfunction BgInR knockdown leads to a severe inhibition of juvenile hormone synthesis in adult female corpora allata, with a concomitant reduction of mRNA levels corresponding to 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase-1, HMG-CoA synthase-2, HMG-CoA reductase and methyl farnesoate epoxidase, phenotype, overview Blattella germanica
1.14.14.127 metabolism the enzyme is important in the biosynthesis and regulation of juvenile hormone in the JH specific pathway Blattella germanica