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Literature summary extracted from

  • Cheng, W.; Ka, Y.W.; Chang, C.C.
    Involvement of dopamine beta-hydroxylase in the neuroendocrine-immune regulatory network of white shrimp, Litopenaeus vannamei (2017), Fish Shellfish Immunol., 68, 92-101 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.17.1 Disulfiram pharmaceutical inhibition of enzyme DBH Penaeus vannamei

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.17.1 Cu2+ enzyme-bound, required for activity Penaeus vannamei

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.17.1 dopamine + ascorbate + O2 Penaeus vannamei
-
 noradrenaline + dehydroascorbate + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.17.1 Penaeus vannamei A0A1I9LDK0
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.17.1 hemocyte
-
 Penaeus vannamei
-
1.14.17.1 hepatopancreas
-
 Penaeus vannamei
-
1.14.17.1 thoracic ganglion
-
 Penaeus vannamei
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.17.1 dopamine + ascorbate + O2
-
 Penaeus vannamei noradrenaline + dehydroascorbate + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.17.1 DBH
-
 Penaeus vannamei
1.14.17.1 dopamine beta-hydroxylase
-
 Penaeus vannamei

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.17.1 ascorbate
-
 Penaeus vannamei

Expression

EC Number Organism Comment Expression
1.14.17.1 Penaeus vannamei enzyme downregulation by LvDBH-dsRNA down

General Information

EC Number General Information Comment Organism
1.14.17.1 evolution the enzyme belongs to the copper type II, ascorbate-dependent monooxygenases Penaeus vannamei
1.14.17.1 malfunction enzyme activity and norepinephrine level in shrimps downregulated by LvDBH-dsRNA are reduced, the treated animals show increased susceptibility to Vibrio alginolyticus infection, significantly lower total hemocyte count, phagocytic activity, clearance efficiency, and resistance to Vibrio alginolyticus infection are observed in shrimp that received LvDBH-dsRNA at 3 days post injection compared to those injected with diethyl pyrocarbonate-water or non-targeting gene-dsRNA Penaeus vannamei
1.14.17.1 physiological function dopamine beta-hydroxylase (DBH) is a copper-containing monooxygenase enzyme that plays an important role in catecholamine synthesis of the neuroendocrine regulatory network. In shrimp, the biosynthesis of catecholamines, including dopamine and norepinephrine, is required for physiological and immunological responses against stress Penaeus vannamei