Literature summary extracted from

Coxam, B.; Neyt, C.; Grassini, D.R.; Le Guen, L.; Smith, K.A.; Schulte-Merker, S.; Hogan, B.M.
Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (cad) regulates Notch signaling and vascular development in zebrafish (2015), Dev. Dyn., 244, 1-9 .

Protein Variants

EC Number	Protein Variants	Comment	Organism
6.3.5.5	P1850T	mutation affects a conserved residue in the linker region of Cad. Mutant animals display reduced lymphatic vessel development and hyperbranching arteries, reminiscent of Notch pathway mutants. Notch signaling is significantly reduced in the mutants	Danio rerio

Organism

EC Number	Organism	UniProt	Comment	Textmining
6.3.5.5	Danio rerio	Q5EI67	trifunctional carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	-

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Release 2023.1 (January 2023)