Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Xu, Q.; Song, Y.; Liu, R.; Chen, Y.; Zhang, Y.; Li, Y.; Zhao, W.; Chang, G.; Chen, G.
    The dopamine beta-hydroxylase gene in Chinese goose (Anas cygnoides) cloning, characterization, and expression during the reproductive cycle (2016), BMC Genet., 17, 48 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.17.1 gene gDBH, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, real-time quantitative PCR enzyme expression analysis Anser cygnoides domesticus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.17.1 dopamine + ascorbate + O2 Anser cygnoides domesticus
-
 noradrenaline + dehydroascorbate + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.17.1 Anser cygnoides domesticus A0A140GN70
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.17.1 endocrine gland
-
 Anser cygnoides domesticus
-
1.14.17.1 hypothalamus
-
 Anser cygnoides domesticus
-
1.14.17.1 additional information gDBH expression is found between the hypothalamus-pituitary and oviduct during the ovulation phase and the broody phase, real-time quantitative PCR enzyme expression analysis. The enzyme expression is higher in animals with higher egg production than in those with low egg production. Analysis of temporal expression patterns of gDBH expression in the hypothalamus, pituitary, ovary, and oviduct tissues during different stages of the goose reproductive cycle, specifically the pre-laying stage, ovulation, oviposition, and the broody phase reveals that the expression is lowest in all tissues during the oviposition phase. It is high in the hypothalamus, ovary, and pituitary in the pre-laying period. High expression of DBH is also found in the cerebrum and cerebellum due to the involvement of norepinephrine and epinephrine in neuroendocrine processes Anser cygnoides domesticus
-
1.14.17.1 oviduct
-
 Anser cygnoides domesticus
-
1.14.17.1 pituitary gland
-
 Anser cygnoides domesticus
-
1.14.17.1 reproductive tissue
-
 Anser cygnoides domesticus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.17.1 dopamine + ascorbate + O2
-
 Anser cygnoides domesticus noradrenaline + dehydroascorbate + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.17.1 DBH
-
 Anser cygnoides domesticus
1.14.17.1 dopamine beta-hydroxylase
-
 Anser cygnoides domesticus
1.14.17.1 gDBH
-
 Anser cygnoides domesticus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.17.1 ascorbate
-
 Anser cygnoides domesticus

General Information

EC Number General Information Comment Organism
1.14.17.1 physiological function dopamine beta-hydroxylase is a critical enzyme in the biosynthesis of catecholamines with a role in neuroendocrine regulation and in avian reproduction. Dopamine beta-hydroxylase catalyzes the conversion of dopamine to norepinephrine in the biosynthesis of catecholamines. The activity of DBH influences the levels of dopamine and the biosynthesis of norepinephrine and epinephrine. The enzyme is important in the nervous system Anser cygnoides domesticus