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Literature summary extracted from

  • Zirpel, B.; Stehle, F.; Kayser, O.
    Production of DELTA9-tetrahydrocannabinolic acid from cannabigerolic acid by whole cells of Pichia (Komagataella) pastoris expressing DELTA9-tetrahydrocannabinolic acid synthase from Cannabis sativa L. (2015), Biotechnol. Lett., 37, 1869-1875 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.21.3.7 expressed in Saccharomyces cerevisiae strain CEN.PK2-1C and Pichia pastoris strain PichiaPink2 Cannabis sativa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.3.7 cannabigerolate + O2 Cannabis sativa
-
 DELTA9-tetrahydrocannabinolate + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.21.3.7 Cannabis sativa Q8GTB6
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.3.7 cannabigerolate + O2
-
 Cannabis sativa DELTA9-tetrahydrocannabinolate + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.21.3.7 DELTA9-tetrahydrocannabinolic acid synthase
-
 Cannabis sativa
1.21.3.7 THCA synthase
-
 Cannabis sativa
1.21.3.7 THCAS
-
 Cannabis sativa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.21.3.7 50
-
-
 Cannabis sativa

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.21.3.7 37
-
 the enzyme remains stable after 9 h at 37°C Cannabis sativa