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Literature summary extracted from

  • Takeda, Y.; Totani, K.; Matsuo, I.; Ito, Y.
    The action of bromoconduritol on ER glucosidase II (2010), Bioorg. Med. Chem. Lett., 20, 5357-5359 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.207 bromoconduritol i.e. 6-bromo-3,4,5-trihydroxycyclohex-1-ene, inhibits both cleavage activities of glucosidase II. The inhibitory activity toward cleavage-2, i.e. cleavage of the second of two alpha1->3 linked Glc residues, is 6fold higher than that toward cleavage-1, i.e. removal of the penultimate Glc residue to generate Glc1Man9GlcNAc2. Inhibition is irreversible Rattus norvegicus
3.2.1.207 castanospermine
-
 Rattus norvegicus
3.2.1.207 deoxynojirimycin
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.207 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.207 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.207 Glc2Man9GlcNAc2 + H2O
-
 Rattus norvegicus GlcMan9GlcNAc2 + beta-D-glucopyranose
-
 ?
3.2.1.207 GlcMan9GlcNAc2 + H2O
-
 Rattus norvegicus Man9GlcNAc2 + beta-D-glucopyranose
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.2.1.207 0.001
-
 cleavage-1, pH 7.4, 37°C Rattus norvegicus castanospermine
3.2.1.207 0.001
-
 cleavage-2, pH 7.4, 37°C Rattus norvegicus castanospermine
3.2.1.207 0.008
-
 cleavage-1, pH 7.4, 37°C Rattus norvegicus deoxynojirimycin
3.2.1.207 0.011
-
 cleavage-2, pH 7.4, 37°C Rattus norvegicus deoxynojirimycin
3.2.1.207 0.041
-
 cleavage-2, pH 7.4, 37°C Rattus norvegicus bromoconduritol
3.2.1.207 0.262
-
 cleavage-1, pH 7.4, 37°C Rattus norvegicus bromoconduritol