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Literature summary extracted from
- 6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes (1999), Biochim. Biophys. Acta, 1438, 47-54 .
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.14.57 | expression in insect cells | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.57 | additional information | not inhibitory or very little effect: alpha-naphthoflavone, sulfaphenazole and tranylcypromine | Homo sapiens | |
| 1.14.14.57 | troleandomycin | 0.01 mM, almost complete inhibition | Homo sapiens |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.14.57 | 0.09 | - |
taurochenodeoxycholate | pH 7.4, 37°C | Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.14.57 | microsome | - |
Homo sapiens | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.57 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.14.57 | liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.57 | lithocholate + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | hyodeoxycholate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| 1.14.14.57 | additional information | isofornm CYP3A4 is the only enzyme tested which is active towards bile acids taurochenodeoxycholate and lithocholate. The enzyme catalyzes an efficient 6alpha-hydroxylation of both taurochenodeoxycholic acid and lithocholic acid | Homo sapiens | ? | - |
? | |
| 1.14.14.57 | taurochenodeoxycholate + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | taurohyocholate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.14.57 | CYP3A4 | - |
Homo sapiens |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.14.14.57 | physiological function | a strong correlation exists between 6alpha-hydroxylation of taurochenodeoxycholic acid, CYP3A levels and testosterone 6beta-hydroxylation. There is also a strong correlation between 6alpha-hydroxylation of lithocholic acid, CYP3A levels and testosterone 6beta-hydroxylation | Homo sapiens |
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