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Literature summary extracted from

  • He, X.; Shoukry, K.; Chu, S.; Yang, J.; Sprecher, H.; Schulz, H.
    Peroxisomes contain DELTA3,5,DELTA2,4-dienoyl-CoA isomerase and thus possess all enzymes required for the beta-oxidation of unsaturated fatty acids by a novel reductase-dependent pathway (1995), Biochem. Biophys. Res. Commun., 215, 15-22 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.3.21 Nycodenz
-
 Rattus norvegicus
5.3.3.21 Triton X-100
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.3.21 mitochondrion
-
 Rattus norvegicus 5739
-
5.3.3.21 peroxisome
-
 Rattus norvegicus 5777
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.3.21 a (3E,5Z)-alka-3,5-dienoyl-CoA Rattus norvegicus
-
 a (2E,4E)-alka-2,4-dienoyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.3.21 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.3.21 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.3.21 3,5,8,11,14-eicosapentaenoyl-CoA 22% and 13% activity in peroxisomes and mitochondria, respectively, compared to 3,5-octadienoyl-CoA Rattus norvegicus 2,4,8,11,14-eicosapentaenoyl-CoA
-
 ?
5.3.3.21 3,5-octadienoyl-CoA 100% activity in peroxisomes and mitochondria Rattus norvegicus 2,4-octadienoyl-CoA
-
 ?
5.3.3.21 3,5-tetradecadienoyl-CoA 29% and 36% activity in peroxisomes and mitochondria, respectively, compared to 3,5-octadienoyl-CoA Rattus norvegicus 2,4-tetradecadienoyl-CoA
-
 ?
5.3.3.21 a (3E,5Z)-alka-3,5-dienoyl-CoA
-
 Rattus norvegicus a (2E,4E)-alka-2,4-dienoyl-CoA
-
 ?

Subunits

EC Number Subunits Comment Organism
5.3.3.21 ? x * 32000, mitochondrial enzyme, SDS-PAGE Rattus norvegicus
5.3.3.21 ? x * 66000, peroxisomal enzyme, SDS-PAGE Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
5.3.3.21 DELTA3,5,DELTA2,4-dienoyl-CoA isomerase
-
 Rattus norvegicus
5.3.3.21 dienoyl-CoA isomerase
-
 Rattus norvegicus