EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
6.3.2.8 | R151W | site-directed mutagenesis | Pseudomonas aeruginosa |
6.3.2.8 | Y246C | site-directed mutagenesis | Pseudomonas aeruginosa |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
6.3.2.8 | (1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]piperidin-2-yl)methanol | - |
Escherichia coli | |
6.3.2.8 | (1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]piperidin-2-yl)methanol | - |
Pseudomonas aeruginosa | |
6.3.2.8 | (1R,2S)-1-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2,3-dihydro-1H-inden-2-ol | - |
Escherichia coli | |
6.3.2.8 | (1R,2S)-1-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2,3-dihydro-1H-inden-2-ol | - |
Pseudomonas aeruginosa | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(2-methoxypyridin-4-yl)ethan-1-ol | - |
Escherichia coli | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(2-methoxypyridin-4-yl)ethan-1-ol | - |
Pseudomonas aeruginosa | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-chloropyridin-4-yl)ethan-1-ol | - |
Escherichia coli | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-chloropyridin-4-yl)ethan-1-ol | - |
Pseudomonas aeruginosa | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-fluorophenyl)ethan-1-ol | - |
Escherichia coli | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-fluorophenyl)ethan-1-ol | - |
Pseudomonas aeruginosa | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-methyl-1,2-oxazol-5-yl)ethan-1-ol | - |
Escherichia coli | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-methyl-1,2-oxazol-5-yl)ethan-1-ol | - |
Pseudomonas aeruginosa | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(4-methoxyphenyl)ethan-1-ol | - |
Escherichia coli | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(4-methoxyphenyl)ethan-1-ol | - |
Pseudomonas aeruginosa | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(pyridin-2-yl)ethan-1-ol | - |
Escherichia coli | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(pyridin-2-yl)ethan-1-ol | - |
Pseudomonas aeruginosa | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(pyridin-3-yl)ethan-1-ol | - |
Escherichia coli | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(pyridin-3-yl)ethan-1-ol | - |
Pseudomonas aeruginosa | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol | - |
Escherichia coli | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol | - |
Pseudomonas aeruginosa | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethan-1-ol | - |
Escherichia coli | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethan-1-ol | - |
Pseudomonas aeruginosa | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2-aminoethyl)carbamate | - |
Escherichia coli | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2-aminoethyl)carbamate | - |
Pseudomonas aeruginosa | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2-hydroxyethyl)carbamate | - |
Escherichia coli | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2-hydroxyethyl)carbamate | - |
Pseudomonas aeruginosa | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2R)-2-(aminomethyl)morpholine-4-carboxylate | - |
Escherichia coli | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2R)-2-(aminomethyl)morpholine-4-carboxylate | - |
Pseudomonas aeruginosa | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl hydroxycarbamate | - |
Escherichia coli | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl hydroxycarbamate | - |
Pseudomonas aeruginosa | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methyl]carbamate | - |
Escherichia coli | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methyl]carbamate | - |
Pseudomonas aeruginosa | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [2-(3-oxopyrazolidin-1-yl)ethyl]carbamate | - |
Escherichia coli | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [2-(3-oxopyrazolidin-1-yl)ethyl]carbamate | - |
Pseudomonas aeruginosa | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [[(4S)-3-methyl-2-oxoimidazolidin-4-yl]methyl]carbamate | - |
Escherichia coli | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [[(4S)-3-methyl-2-oxoimidazolidin-4-yl]methyl]carbamate | - |
Pseudomonas aeruginosa | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol | - |
Escherichia coli | |
6.3.2.8 | (2R)-2-([4-[(5-tert-butyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol | - |
Pseudomonas aeruginosa | |
6.3.2.8 | (2R)-2-cyclohexyl-2-[(4-[[5-(propan-2-yl)-1H-pyrazol-3-yl]amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]ethan-1-ol | - |
Escherichia coli | |
6.3.2.8 | (2R)-2-cyclohexyl-2-[(4-[[5-(propan-2-yl)-1H-pyrazol-3-yl]amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]ethan-1-ol | - |
Pseudomonas aeruginosa | |
6.3.2.8 | (2S)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol | - |
Escherichia coli | |
6.3.2.8 | (2S)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol | - |
Pseudomonas aeruginosa | |
6.3.2.8 | (2S)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethan-1-ol | - |
Escherichia coli | |
6.3.2.8 | (2S)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethan-1-ol | - |
Pseudomonas aeruginosa | |
6.3.2.8 | (2S)-2-cyclohexyl-2-([4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)ethan-1-ol | - |
Escherichia coli | |
6.3.2.8 | (2S)-2-cyclohexyl-2-([4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)ethan-1-ol | - |
Pseudomonas aeruginosa | |
6.3.2.8 | (2S)-2-cyclohexyl-2-[(4-[[5-(propan-2-yl)-1H-pyrazol-3-yl]amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]ethan-1-ol | - |
Escherichia coli | |
6.3.2.8 | (2S)-2-cyclohexyl-2-[(4-[[5-(propan-2-yl)-1H-pyrazol-3-yl]amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]ethan-1-ol | - |
Pseudomonas aeruginosa | |
6.3.2.8 | 2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(oxan-4-yl)ethan-1-ol | - |
Escherichia coli | |
6.3.2.8 | 2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(oxan-4-yl)ethan-1-ol | - |
Pseudomonas aeruginosa | |
6.3.2.8 | 2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-3-methylbutan-1-ol | - |
Escherichia coli | |
6.3.2.8 | 2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-3-methylbutan-1-ol | - |
Pseudomonas aeruginosa | |
6.3.2.8 | additional information | a class of pyrazolopyrimidines with subnanomolar potency against both Escherichia coli and Pseudomonas aeruginosa MurC enzymes is constructed, which demonstrate a concomitant bactericidal activity against efflux-deficient strains. The compounds selectively inhibit peptidoglycan biosynthesis. In the presence of permeability enhancers such as colistin, pyrazolopyrimidines exhibit low micromolar MIC against the wild-type bacteria, thereby, indicating permeability and efflux as major challenges for this chemical series. Inhibitors evaluation and binding mode of pyrazolopyrimidines, docking study, overview | Escherichia coli | |
6.3.2.8 | additional information | a class of pyrazolopyrimidines with subnanomolar potency against both Escherichia coli and Pseudomonas aeruginosa MurC enzymes is constructed, which demonstrate a concomitant bactericidal activity against efflux-deficient strains. The compounds selectively inhibit peptidoglycan biosynthesis. In the presence of permeability enhancers such as colistin, pyrazolopyrimidines exhibit low micromolar MIC against the wild-type bacteria, thereby, indicating permeability and efflux as major challenges for this chemical series. Inhibitors evaluation and binding mode of pyrazolopyrimidines, docking study, overview. The antibiotics linezolid, erythromycin, meropenem, ampicillin, and ofloxacin modulate the MIC values of pyrazolopyrimidine compounds in strain Pae546 | Pseudomonas aeruginosa |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
6.3.2.8 | Mg2+ | required | Escherichia coli | |
6.3.2.8 | Mg2+ | required | Pseudomonas aeruginosa |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.3.2.8 | ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine | Escherichia coli | - |
ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine | - |
? | |
6.3.2.8 | ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine | Pseudomonas aeruginosa | - |
ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine | - |
? | |
6.3.2.8 | ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine | Pseudomonas aeruginosa Pae546 | - |
ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
6.3.2.8 | Escherichia coli | - |
- |
- |
6.3.2.8 | Pseudomonas aeruginosa | - |
- |
- |
6.3.2.8 | Pseudomonas aeruginosa Pae546 | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.3.2.8 | ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine | - |
Escherichia coli | ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine | - |
? | |
6.3.2.8 | ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine | - |
Pseudomonas aeruginosa | ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine | - |
? | |
6.3.2.8 | ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine | - |
Pseudomonas aeruginosa Pae546 | ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
6.3.2.8 | MurC | - |
Escherichia coli |
6.3.2.8 | MurC | - |
Pseudomonas aeruginosa |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
6.3.2.8 | ATP | - |
Escherichia coli | |
6.3.2.8 | ATP | - |
Pseudomonas aeruginosa |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
6.3.2.8 | 0.0000005 | - |
below, pH and temperature not specified in the publication | Pseudomonas aeruginosa | (1R,2S)-1-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2,3-dihydro-1H-inden-2-ol | |
6.3.2.8 | 0.0000005 | - |
below, pH and temperature not specified in the publication | Pseudomonas aeruginosa | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-fluorophenyl)ethan-1-ol | |
6.3.2.8 | 0.0000005 | - |
below, pH and temperature not specified in the publication | Pseudomonas aeruginosa | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [[(4S)-3-methyl-2-oxoimidazolidin-4-yl]methyl]carbamate | |
6.3.2.8 | 0.0000006 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol | |
6.3.2.8 | 0.0000006 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2R)-2-(aminomethyl)morpholine-4-carboxylate | |
6.3.2.8 | 0.0000007 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2-aminoethyl)carbamate | |
6.3.2.8 | 0.000001 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethan-1-ol | |
6.3.2.8 | 0.000001 | - |
pH and temperature not specified in the publication | Escherichia coli | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methyl]carbamate | |
6.3.2.8 | 0.0000012 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(2-methoxypyridin-4-yl)ethan-1-ol | |
6.3.2.8 | 0.0000013 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methyl]carbamate | |
6.3.2.8 | 0.000002 | - |
pH and temperature not specified in the publication | Escherichia coli | (1R,2S)-1-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2,3-dihydro-1H-inden-2-ol | |
6.3.2.8 | 0.000002 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2-hydroxyethyl)carbamate | |
6.3.2.8 | 0.000003 | - |
pH and temperature not specified in the publication | Escherichia coli | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2-hydroxyethyl)carbamate | |
6.3.2.8 | 0.000003 | - |
pH and temperature not specified in the publication | Escherichia coli | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [[(4S)-3-methyl-2-oxoimidazolidin-4-yl]methyl]carbamate | |
6.3.2.8 | 0.000004 | - |
pH and temperature not specified in the publication | Escherichia coli | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-fluorophenyl)ethan-1-ol | |
6.3.2.8 | 0.000004 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(4-methoxyphenyl)ethan-1-ol | |
6.3.2.8 | 0.000004 | - |
pH and temperature not specified in the publication | Escherichia coli | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2-aminoethyl)carbamate | |
6.3.2.8 | 0.000005 | - |
pH and temperature not specified in the publication | Escherichia coli | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethan-1-ol | |
6.3.2.8 | 0.000005 | - |
pH and temperature not specified in the publication | Escherichia coli | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2R)-2-(aminomethyl)morpholine-4-carboxylate | |
6.3.2.8 | 0.000005 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | (2S)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol | |
6.3.2.8 | 0.000006 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl hydroxycarbamate | |
6.3.2.8 | 0.000007 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-methyl-1,2-oxazol-5-yl)ethan-1-ol | |
6.3.2.8 | 0.000007 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [2-(3-oxopyrazolidin-1-yl)ethyl]carbamate | |
6.3.2.8 | 0.000008 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-chloropyridin-4-yl)ethan-1-ol | |
6.3.2.8 | 0.000008 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(pyridin-2-yl)ethan-1-ol | |
6.3.2.8 | 0.000008 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | (2R)-2-cyclohexyl-2-[(4-[[5-(propan-2-yl)-1H-pyrazol-3-yl]amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]ethan-1-ol | |
6.3.2.8 | 0.000008 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | (2S)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethan-1-ol | |
6.3.2.8 | 0.000009 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(pyridin-3-yl)ethan-1-ol | |
6.3.2.8 | 0.00001 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | (2R)-2-([4-[(5-tert-butyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol | |
6.3.2.8 | 0.000011 | - |
pH and temperature not specified in the publication | Escherichia coli | (2S)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethan-1-ol | |
6.3.2.8 | 0.000011 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | 2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(oxan-4-yl)ethan-1-ol | |
6.3.2.8 | 0.000013 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | 2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-3-methylbutan-1-ol | |
6.3.2.8 | 0.000015 | - |
pH and temperature not specified in the publication | Escherichia coli | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(2-methoxypyridin-4-yl)ethan-1-ol | |
6.3.2.8 | 0.000021 | - |
pH and temperature not specified in the publication | Escherichia coli | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(4-methoxyphenyl)ethan-1-ol | |
6.3.2.8 | 0.00004 | - |
pH and temperature not specified in the publication | Escherichia coli | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(pyridin-2-yl)ethan-1-ol | |
6.3.2.8 | 0.00005 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | (2S)-2-cyclohexyl-2-([4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)ethan-1-ol | |
6.3.2.8 | 0.000052 | - |
pH and temperature not specified in the publication | Escherichia coli | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl hydroxycarbamate | |
6.3.2.8 | 0.000057 | - |
pH and temperature not specified in the publication | Escherichia coli | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-chloropyridin-4-yl)ethan-1-ol | |
6.3.2.8 | 0.00006 | - |
pH and temperature not specified in the publication | Escherichia coli | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-methyl-1,2-oxazol-5-yl)ethan-1-ol | |
6.3.2.8 | 0.00006 | - |
pH and temperature not specified in the publication | Escherichia coli | (2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [2-(3-oxopyrazolidin-1-yl)ethyl]carbamate | |
6.3.2.8 | 0.0001 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | (2S)-2-cyclohexyl-2-[(4-[[5-(propan-2-yl)-1H-pyrazol-3-yl]amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]ethan-1-ol | |
6.3.2.8 | 0.000101 | - |
pH and temperature not specified in the publication | Escherichia coli | 2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(oxan-4-yl)ethan-1-ol | |
6.3.2.8 | 0.000188 | - |
pH and temperature not specified in the publication | Escherichia coli | 2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-3-methylbutan-1-ol | |
6.3.2.8 | 0.001 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | (1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]piperidin-2-yl)methanol |
EC Number | General Information | Comment | Organism |
---|---|---|---|
6.3.2.8 | metabolism | the enzyme is essentially involved in the bacterial peptidoglycan biosynthesis pathway. MurC, the first of four Mur ligases, ligates L-alanine to UDP-N-acetylmuramic acid, initiating the synthesis of pentapeptide precursor | Escherichia coli |
6.3.2.8 | metabolism | the enzyme is essentially involved in the bacterial peptidoglycan biosynthesis pathway. MurC, the first of four Mur ligases, ligates L-alanine to UDP-N-acetylmuramic acid, initiating the synthesis of pentapeptide precursor | Pseudomonas aeruginosa |
6.3.2.8 | physiological function | the enzyme is essential for peptidoglycan biosynthesis. Peptidoglycan is an essential cell wall component of both gram-positive and gram-negative bacteria that protects the cytoplasmic membrane from osmotic stress | Escherichia coli |
6.3.2.8 | physiological function | the enzyme is essential for peptidoglycan biosynthesis. Peptidoglycan is an essential cell wall component of both gram-positive and gram-negative bacteria that protects the cytoplasmic membrane from osmotic stress | Pseudomonas aeruginosa |