Literature summary extracted from

Edgar, S.; Zhou, K.; Qiao, K.; King, J.R.; Simpson, J.H.; Stephanopoulos, G.
Mechanistic insights into taxadiene epoxidation by taxadiene-5alpha-hydroxylase (2016), ACS Chem. Biol., 11, 460-469 .

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.14.14.176	expressed in Saccharomyces cerevisiae and Escherichia coli	Taxus cuspidata

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.14.14.176	taxa-4,11-diene + [reduced NADPH-hemoprotein reductase] + O2	Taxus cuspidata	-	taxa-4(20),11-dien-5alpha-ol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.14.176	Taxus cuspidata	Q6WG30	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.14.176	taxa-4,11-diene + [reduced NADPH-hemoprotein reductase] + O2	-	Taxus cuspidata	taxa-4(20),11-dien-5alpha-ol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.14.14.176	5alphaCYP	-	Taxus cuspidata
1.14.14.176	CYP725A4	-	Taxus cuspidata
1.14.14.176	taxadiene-5alpha-hydroxylase	-	Taxus cuspidata

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)