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Literature summary extracted from

  • Sarwono, A.E.Y.; Suganuma, K.; Mitsuhashi, S.; Okada, T.; Musinguzi, S.P.; Shigetomi, K.; Inoue, N.; Ubukata, M.
    Identification and characterization of guanosine 5'-monophosphate reductase of Trypanosoma congolense as a drug target (2017), Parasitol. Int., 66, 537-544 .
    View publication on PubMed

Application

EC Number Application Comment Organism
1.7.1.7 drug development the enzyme is a target for the design of trypanocidal agents, e.g. based on mycophenolic acid Trypanosoma congolense

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.7.1.7 gene TCIL3000_5_1940, recombinant expression in Escherichia coli Trypanosoma congolense

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.7.1.7 Mycophenolic acid MPA Trypanosoma congolense

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.7.1.7 glycosome constitutive expression of TcGMPR in glycosomes at all of the parasite's developmental stages Trypanosoma congolense 20015
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.7.1.7 GMP + NADPH + H+ Trypanosoma congolense
-
 IMP + NH3 + NADP+
-
 ?
1.7.1.7 GMP + NADPH + H+ Trypanosoma congolense IL3000
-
 IMP + NH3 + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.7.1.7 Trypanosoma congolense G0UMT0
-
-
1.7.1.7 Trypanosoma congolense IL3000 G0UMT0
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.7.1.7 GMP + NADPH + H+
-
 Trypanosoma congolense IMP + NH3 + NADP+
-
 ?
1.7.1.7 GMP + NADPH + H+
-
 Trypanosoma congolense IL3000 IMP + NH3 + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.7.1.7 GMPR
-
 Trypanosoma congolense
1.7.1.7 guanosine 5'-monophosphate reductase
-
 Trypanosoma congolense
1.7.1.7 TcGMPR
-
 Trypanosoma congolense
1.7.1.7 TCIL3000_5_1940
-
 Trypanosoma congolense

Cofactor

EC Number Cofactor Comment Organism Structure
1.7.1.7 NADPH
-
 Trypanosoma congolense

General Information

EC Number General Information Comment Organism
1.7.1.7 physiological function enzyme GMPR modulates the concentration of intracellular guanosine in the pathogen Trypanosoma congolense