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Literature summary extracted from

  • Hossain, M.S.; Le, C.Q.; Joseph, E.; Nguyen, T.Q.; Johnson-Winters, K.; Foss, F.W.
    Convenient synthesis of deazaflavin cofactor FO and its activity in F420-dependent NADP reductase (2015), Org. Biomol. Chem., 13, 5082-5085 .
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.1.40 additional information
-
 additional information analysis of the F420 redox moiety (FO)-dependent NADP+/NADPH redox process by stopped-flow spectrophotometry, steady state kinetics, overview Archaea

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.1.40 reduced coenzyme F420 + NADP+ Archaea
-
 oxidized coenzyme F420 + NADPH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.40 Archaea
-
 methanogenic
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.40 additional information F420 and the F420 redox moiety, FO, are phenolic 5-deazaflavin cofactors that complement nicotinamide and flavin redox coenzymes in biochemical oxidoreductases and photocatalytic systems. Specifically, these 5-deazaflavins lack the single electron reactivity with O2 of riboflavin-derived coenzymes (FMN and FAD), and, in general, have a more negative redox potential than NAD(P)+. A convenient synthesis of FO is achieved by improving the redox stability of synthetic intermediates containing a polar, electron-rich aminophenol fragment, Fno enzyme activity is restored with FO in the absence of F420, method optimization, overview Archaea ?
-
 ?
1.5.1.40 reduced coenzyme F420 + NADP+
-
 Archaea oxidized coenzyme F420 + NADPH + H+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.5.1.40 F420-dependent NADP+ oxidoreductase
-
 Archaea
1.5.1.40 Fno
-
 Archaea

General Information

EC Number General Information Comment Organism
1.5.1.40 physiological function F420-dependent NADP+ oxidoreductase (Fno) is critical to the conversion of CO2 to CH4 by methanogenic archaea, while the F420 redox moiety, FO, functions as a light-harvesting agent in DNA repair Archaea