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Literature summary extracted from

  • Cervelli, M.; Polticelli, F.; Fiorucci, L.; Angelucci, E.; Federico, R.; Mariottini, P.
    Inhibition of acetylpolyamine and spermine oxidases by the polyamine analogue chlorhexidine (2013), J. Enzyme Inhib. Med. Chem., 28, 463-467 .
No PubMed abstract available

Application

EC Number Application Comment Organism
1.5.3.16 medicine the selective inhibitors of spermine oxidase represent an important tool for the development of novel anti-neoplastic drugs Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.5.3.16 expression in Escherichia coli Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.3.16 Chlorhexidine poor inhibitor Mus musculus
1.5.3.16 N,N'-bis(2,3-butadienyl)-1,4-butanediamine i.e. MDL 72527. Binding of the inhibitor to the enzyme takes place essentially only through a hydrophobic interaction with Trp62 side chain Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.3.16 0.09
-
 spermine pH 8.3, 25°C Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.3.16 spermine + O2 + H2O Mus musculus the enzyme is involved in the catabolism of polyamines spermidine + 3-aminopropanal + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.3.16 Mus musculus Q99K82
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.3.16 spermine + O2 + H2O
-
 Mus musculus spermidine + 3-aminopropanal + H2O2
-
 ?
1.5.3.16 spermine + O2 + H2O the enzyme is involved in the catabolism of polyamines Mus musculus spermidine + 3-aminopropanal + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.5.3.16 SMO
-
 Mus musculus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.5.3.16 4.5
-
 spermine pH 8.3, 25°C Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.5.3.16 0.00055
-
 Chlorhexidine pH 8.3, 25°C Mus musculus

General Information

EC Number General Information Comment Organism
1.5.3.16 metabolism the enzyme is involved in the catabolism of polyamines Mus musculus