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Literature summary extracted from

  • Rodriguez-Saiz, M.; Barredo, J.L.; Moreno, M.A.; Fernandez-Canon, J.M.; Penalva, M.A.; Diez, B.
    Reduced function of a phenylacetate-oxidizing cytochrome p450 caused strong genetic improvement in early phylogeny of penicillin-producing strains (2001), J. Bacteriol., 183, 5465-5471 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.14.14.54 L181F the mutation is responsible for the reduced function of the enzyme Penicillium chrysogenum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.54 phenylacetate + [reduced NADPH-hemoprotein reductase] + O2 Penicillium chrysogenum
-
 (2-hydroxyphenyl)acetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.54 phenylacetate + [reduced NADPH-hemoprotein reductase] + O2 Penicillium chrysogenum NRRL 1951
-
 (2-hydroxyphenyl)acetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.54 Penicillium chrysogenum Q9URR6
-
-
1.14.14.54 Penicillium chrysogenum NRRL 1951 Q9URR6
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.54 phenylacetate + [reduced NADPH-hemoprotein reductase] + O2
-
 Penicillium chrysogenum (2-hydroxyphenyl)acetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.54 phenylacetate + [reduced NADPH-hemoprotein reductase] + O2
-
 Penicillium chrysogenum NRRL 1951 (2-hydroxyphenyl)acetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.54 PA 2-hydroxylase
-
 Penicillium chrysogenum
1.14.14.54 phaA
-
 Penicillium chrysogenum
1.14.14.54 phenylacetate, NAD(P):oxygen oxidoreductase (2-hydroxylating)
-
 Penicillium chrysogenum